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PPP2R3B codes for the PR70 protein, a regulatory substrate-recognizing subunit of protein phosphatase 2A. PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing CDC6 (show CDC6 Proteins)-chromatin licensing and CDT1 (show CDT1 Proteins) interaction
Results show the crystal structure of PR48/PR70, at 2.0 A degrees resolution with two domain elongated structure and two Ca2 (show CA2 Proteins)+ binding EF-hands Scattering data.
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''.
, PP2A, subunit B, PR48 isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta
, serine/threonine protein phosphatase 2A, 48kDa regulatory subunit B
, serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
, PP2A B'' subunit PR48
, uncharacterized protein LOC682033