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High SGPL1 expression is associated with Huntington's disease.
These results show that both a primary defect in cholesterol trafficking and S1P lyase deficiency cause overlapping phenotypic alterations, and challenge the present view on the role of sphingosine in lysosomal Ca(2+) homeostasis.
Partial genetic deletion of Sgpl1 protected mice against ventilator induced lung injury.
Study identifies sphingosine 1-phosphate metabolism as a novel player in modulating synaptic architecture and plasticity.
SGPL1 modulates neuronal autophagy via phosphatidylethanolamine production
Study verifies the role of a high-ranked gene in dysregulation of sphingolipid metabolism in the disease and demonstrate that inhibiting the enzyme, sphingosine-1-phosphate lyase 1 (SPL), has neuroprotective effects in Huntington's disease models.
Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury, and the role in this process of S1P lyase has been described. (Review)
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency
Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.
deleting SPL in CD11c(+) dendritic cells (DCs), rather than thymic epithelial cells or other stromal cells, disrupts the sphingosine-1-phosphate gradient, preventing egress.
The sphingosine-1-phosphate lyase contributes to the restriction of Legionella pneumophila in murine macrophages.
Studies suggest that S1PL is a novel endogenous suppressor of pulmonary fibrosis in human idiopathic pulmonary fibrosis and animal models.
Although the observed inhibitory effect was not as strong as that of 4-deoxypyridoxine (a VB6 analog SPL inhibitor), these findings may be useful for further understanding the mechanism of action of THI.
upregulation of multidrug resistance transporters contributes to the chemoresistance of S1P lyase-deficient MEFs
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.
Findings suggest that sphingosine phosphate lyase (S1P lyase) expressed in the thymic medullary perivascular spaces keeps the tissue sphingosine 1-phosphate low around the vessels and promotes thymic egress via up-regulation of S1P receptor 1 (S1P1).
Data indicate that SGPL1 sphingosine 1-phosphate lyase (aldolase) mRNA is significantly increased in the periinfarct cortex.
Leukocyte Sgpl1 as critical factor in monocyte macrophage differentiation and function.
Inducible Sgpl1 knockout mice are protected in experimental autoimmune encephalomyelitis (EAE).
Sphingosine-1-phosphate lyase has many undiscovered physiological functions apart from its role in immunity
describe the sequential expression and localization of the endogenous S1P regulators SGPP-1 and SGPL-1 and highlight their contribution to the sphingolipid rheostat in inflammation.
Data show that sphingosine kinase 1 (SPHK1) was significantly upregulated in oral squamous cell carcinoma (OSCC) tissues and low levels of sphingosine-1-phosphate lyase 1 (SGPL1) mRNA correlated with a worse overall survival, and that sphingosine-1-phosphate receptor 2 (S1PR2) is over-expressed in a subset of tumours, which in part mediates sphingosine 1-phosphate (S1P)-induced migration of OSCC cells.
Loss of SGPL1 function is associated with congenital nephrotic syndrome (CNS), adrenal calcifications, and hypogonadism.
results demonstrate that Sphingosine 1-phosphate lyase (SPL) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL, which provides a mechanistic understanding of the pro-IFN activity of SPL
Exposure to the combination of 100 muM genistein and 10 nM calcitriol reduced the number of proliferative cells to control levels, increased ERb and VDR expression, and reduced extracellular acidification (40%) as well as respiratory activity (70%), primarily in MG-63 cells..strong overexpression SGPL1, which irreversibly degrades sphingosine-1-phosphate thereby, generating ethanolamine
Overexpression of sphingosine-1-phosphate lyase 1 (SGPL1), reverse the interleukin-8 (IL-8) secretion enhancing effect of microRNA miR-125b in trophoblast cell line HTR8/SVneo cells.
Report a candidate gene (SGPL1) for autosomal recessive Charcot-Marie-Tooth disease with atypical disease course. Studies in patient-derived biosamples suggested that this phenotype is due to partial loss of SGPL1 function. Neuron-specific downregulation of the Drosophila orthologue impaired the morphology of the neuromuscular junction and caused progressive neurodegeneration
increased SK and SPL mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.
SPHK1:SGPL1 ratio correlated with increased cellular sphingosine-1-phosphate (S1P), and S1P correlated with drug resistance (IC50).
Results show that dissociation of SHP-1 from spinophilin is followed by an increase in the binding of spinophilin to PP1.
S1P lyase - by facilitating S1P1 receptor recycling - is essential for S1P-mediated sustained signaling
results highlight the importance of S1P in AD suggesting the existence of a global deregulation of S1P signaling in this disease from its synthesis by SphK1 and degradation by SPL to its signaling by the S1P1 receptor.
The cells expressing SGPL1 in the parenchyma were CD68(+) APCs.
Data show that a easy assay for 2-hydroxyacyl-CoA lyase (HACL1) and sphingosine-1-phosphate lyase (SGPL1) activities was developed.
SPL expression and activity are downregulated in cancerous tissues, there is a relationship between loss of SPL expression and prostate cancer aggressiveness.
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
sphingosine-1-phosphate lyase 1
, SP-lyase 1
, SPL 1
, sphingosine-1-phosphate aldolase
, sphingosine phosphate lyase 1