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These results show that both a primary defect in cholesterol trafficking and S1P (show S1PR1 Proteins) lyase deficiency cause overlapping phenotypic alterations, and challenge the present view on the role of sphingosine in lysosomal Ca(2 (show CA2 Proteins)+) homeostasis.
Partial genetic deletion of Sgpl1 protected mice against ventilator induced lung injury.
SGPL1 modulates neuronal autophagy via phosphatidylethanolamine production
Study verifies the role of a high-ranked gene in dysregulation of sphingolipid metabolism in the disease and demonstrate that inhibiting the enzyme, sphingosine-1-phosphate lyase 1 (SPL), has neuroprotective effects in Huntington's disease models.
Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P (show S1PR1 Proteins)) in acute lung injury, and the role in this process of S1P (show S1PR1 Proteins) lyase has been described. (Review)
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis (show LBR Proteins) and adrenal insufficiency
deleting SPL in CD11c (show ITGAX Proteins)(+) dendritic cells (DCs), rather than thymic epithelial cells or other stromal cells, disrupts the sphingosine-1-phosphate gradient, preventing egress.
Studies suggest that S1PL is a novel endogenous suppressor of pulmonary fibrosis in human idiopathic pulmonary fibrosis and animal models.
Although the observed inhibitory effect was not as strong as that of 4-deoxypyridoxine (a VB6 analog SPL inhibitor), these findings may be useful for further understanding the mechanism of action of THI.
upregulation of multidrug resistance transporters contributes to the chemoresistance of S1P (show S1PR1 Proteins) lyase-deficient MEFs
describe the sequential expression and localization of the endogenous S1P (show MBTPS1 Proteins) regulators SGPP-1 (show SGPP1 Proteins) and SGPL-1 and highlight their contribution to the sphingolipid rheostat in inflammation.
Data show that sphingosine kinase 1 (SPHK1 (show SPHK1 Proteins)) was significantly upregulated in oral squamous cell carcinoma (OSCC) tissues and low levels of sphingosine-1-phosphate lyase 1 (SGPL1) mRNA correlated with a worse overall survival, and that sphingosine-1-phosphate receptor 2 (S1PR2 (show S1PR2 Proteins)) is over-expressed in a subset of tumours, which in part mediates sphingosine 1-phosphate (S1P (show MBTPS1 Proteins))-induced migration of OSCC cells.
Loss of SGPL1 function is associated with congenital nephrotic syndrome (CNS), adrenal calcifications, and hypogonadism.
results demonstrate that Sphingosine 1-phosphate lyase (SPL) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (show IKBKE Proteins) and SPL, which provides a mechanistic understanding of the pro-IFN activity of SPL
Exposure to the combination of 100 muM genistein and 10 nM calcitriol reduced the number of proliferative cells to control levels, increased ERb (show ESR2 Proteins) and VDR (show CYP27B1 Proteins) expression, and reduced extracellular acidification (40%) as well as respiratory activity (70%), primarily in MG-63 cells..strong overexpression SGPL1, which irreversibly degrades sphingosine-1-phosphate thereby, generating ethanolamine
Overexpression of sphingosine-1-phosphate lyase 1 (SGPL1), reverse the interleukin-8 (IL-8 (show IL8 Proteins)) secretion enhancing effect of microRNA miR (show MLXIP Proteins)-125b in trophoblast cell line HTR8/SVneo cells.
Report a candidate gene (SGPL1) for autosomal recessive Charcot-Marie-Tooth disease with atypical disease course. Studies in patient-derived biosamples suggested that this phenotype is due to partial loss of SGPL1 function. Neuron-specific downregulation of the Drosophila orthologue impaired the morphology of the neuromuscular junction and caused progressive neurodegeneration
increased SK and SPL mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
sphingosine-1-phosphate lyase 1
, SP-lyase 1
, SPL 1
, sphingosine-1-phosphate aldolase
, sphingosine phosphate lyase 1