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anti-Human Tiparp Antibodies:
anti-Mouse (Murine) Tiparp Antibodies:
anti-Rat (Rattus) Tiparp Antibodies:
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Cow (Bovine) Polyclonal Tiparp Primary Antibody for WB - ABIN2778114
Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: The LIFEdb database in 2006. in Nucleic acids research 2005
Show all 2 Pubmed References
circHECTD1 functions as an endogenous MIR142 (microRNA 142) sponge to inhibit MIR142 activity, resulting in the inhibition of TIPARP (TCDD inducible poly[ADP-ribose] polymerase) expression with subsequent inhibition of astrocyte activation via macroautophagy/autophagy.
Mutation of cysteine 39 to alanine resulted in a small, but significant, reduction in TCDD inducible poly(ADP-ribose) polymerase protein (TIPARP) autoribosylation activity.
TIPARP is a viral RNA-sensing pattern recognition receptors that mediates antiviral responses triggered by BAX- and BAK1-dependent mitochondrial damage
Moreover, time course and promoter activity assays suggest that TIPARP and TIPARP-AS1 work in concert to regulate AHR signaling. Collectively, these data show an added level of complexity in the AHR signaling cascade which involves lncRNAs, whose functions remain poorly understood.
these data identify a new mechanism of LXR regulation that involves TIPARP, ADP-ribosylation and MACROD1.
Knockdown of TiPARP, but not AHRR, increased 2,3,7,8-tetrachlorodibenzo-p-dioxin - induced CYP1A1 mRNA and AHR protein levels.
Single nucleotide polymorphism in TIPARP is associated with ovarian cancer.
TIPARP (DKFZp434J214) gene is amplified in HNSCC. TIPARP, FLJ22693 and ZAP proteins with TPH, WW and PARP-like domains constitute the TIPARP family.
Tiparp(-/-) mice have increased sensitivity to 3-methylcholanthrene-induced liver toxicity.
this study shows that aryl hydrocarbon receptor upregulates expression of TIPARP, which in turn causes downregulation of the IFN type I response
Loss of Tiparp increases sensitivity to dioxin toxicity and lethality.
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants.
TCDD-inducible poly(ADP-ribose) polymerase
, TCDD-inducible poly [ADP-ribose] polymerase
, TCDD-inducible poly [ADP-ribose] polymerase-like
, ADP-ribosyltransferase diphtheria toxin-like 14
, poly [ADP-ribose] polymerase 7