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anti-Human ALOX12 Antibodies:
anti-Mouse (Murine) ALOX12 Antibodies:
anti-Rat (Rattus) ALOX12 Antibodies:
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Human Polyclonal ALOX12 Primary Antibody for ELISA, WB - ABIN559854
Gregus, Dumlao, Wei, Norris, Catella, Meyerstein, Buczynski, Steinauer, Fitzsimmons, Yaksh, Dennis: Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013
ALOX15 orthologs, commonly known as 12/15-lipoxygenases, were suggested to exhibit mainly arachidonic acid 12-lipoxygenating specificity in mammals ranked in evolution lower than gibbons and 15-lipoxygenating specificity in the higher ranking primates [Review].
ALOX12 rs14309 GG genotype expression was found to be significantly associated with Cardiovascular events in patients with Diabetic Nephropathy.
Data suggest that ALOX12 is involved in oxidative stress and endoplasmic reticulum stress in liver and other tissues leading to non-alcoholic fatty liver disease. [REVIEW]
12(S)-HETrE, a 12-lipoxygenase oxylipin of dihomo-gamma-linolenic acid, inhibits thrombosis via Galphas signaling in platelets.
Results identified a novel ALOX12 locus (indicated by two SNPs in perfect linkage disequilibrium: rs1042357 and rs10852889) that moderated the association between PTSD and reduced thickness of the right prefrontal cortex.
The regulation of important oxylipin metabolic genes in peripheral blood mononuclear cells varied with the extent of change in arachidonic acid concentrations in the case of PTGS1 and ALOX12 regulation.
ITGB4 stimulation leads to recruitment of 12-LOX from the cytosol to the membrane.
In the highest tertile with ALOX12.
the amount of LPL expressed in muscle and heart governed both the binding of chylomicron particles and the assimilation of chylomicron lipids in the tissue.
Results suggest that Alox12 protein polymorphisms did not discriminate for psoriasis severity.
Results indicate that secreted phospholipase A2 IIA (sPLA2-IIA) as an enzyme working in concert with platelet microparticles (MPs) 12-lipoxygenase (12-LO) to promote internalization.
IGF-1 reduces lipid oxidation and foam cell formation via downregulation of 12/15-LOX to prevent atherosclerosis.
The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease
The costaining of pancreatic polypeptide and vimentin suggests that 12-LO participates in the process leading to beta-cell dedifferentiation in the islet.
The ALOX12 levels were relatively decreased in nasal polyp tissue.
Inhibition of 12-LOX activity significantly sensitizes prostate cancer cells to radiation.
Our goal was to investigate if 12-LOX and/or PAI-1 in patient's plasma could be used to predict outcome of the disease.
There was no statistically significant difference in expression of ALOX12 mRNA in cholesteatoma vs. control tissue.
This study demonstrated the critical role ALOX12 plays in T. gondii infection in humans, using a monocytic cell line with an ALOX12 knockdown.
12-LOX 261Arg > Gln polymorphism is associated with rectal cancer.
Data show that the coordinated action of phospholipase A2 IIA (sPLA2-IIA) and 12-lipoxygenase (12-LO) promotes inflammatory arthritis.
Data indicate that 12/15-LO knockout (KO) mice were protected from high fat (HF) diet with high dietary omega6/omega3 ratio (11ratio1, HFH)-induced fatty liver.
These results suggest that cardiac 12/15-LOX-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy and that inhibition of 12/15-LOX could be a novel treatment for this condition.
EET-heme oxygenase-1 crosstalk as an important cytoprotective mechanism in the amelioration of vascular and adipocyte dysfunction resulting from diet-induced obesity.
Overexpression of 15-lipoxygenase increases anxiety behavior in female mice.
Findings suggest 12/15-LOX expressed in non-epithelial cells such as macrophages and fibroblasts leads to bronchial epithelial injury.
Data indicate that intravenous injection of B16F10 melanoma cells caused lung nodule formation, which was markedly attenuated in 12/15-Lipoxygenase (12/15-LOX) null mice.
Following middle cerebral artery occlusion to induce stroke, immunohistochemistry shows both Sema3A and 12/15-LOX are increased in the cortex up to 2 wk.
ALOX12 may have a role in growth of breast cancer, and its inhibition may be a strategy for inhibiting tumor growth
IT delivery of 12-LOX metabolites of arachidonic acid 12(S)-HpETE, 12(S)-HETE, HXA(3), or HXB(3) evoked profound, persistent tactile allodynia, but 12(S)-HpETE and HXA(3) produced relatively modest, transient heat hyperalgesia
These data indicate that 12/15-LO and its metabolites have a prominent antifibrotic role during dermal fibrosis.
reduction of alox12 activity or expression could provide a new therapeutic target to reduce ER stress and
Arachidonic acid epoxygenase and 12(S)-lipoxygenase jointly produce a hitherto uncharacterized compound acting as oxygen messenger in the ductus arteriosus.
Increased expression of 12/15LO in the vessel wall enhances Id3-dependent cell proliferation, fibronectin deposition, and neointimal formation in response to carotid artery injury.
12/15-LOX and AIF are sequential actors in a common cell death pathway that may contribute to stroke-induced brain damage.
In the developing epidemis, DeltaNp63alpha directly induces the expression of Alox12, a gene involved in epidermal barrier formation, by interacting with a response element in the promoter of Alox12.
12/15LO mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding
demonstrates 12-lipoxygenase and some 15-lipoxygenase enzyme activity
, arachidonate 12-lipoxygenase, 12S-type
, platelet 12-LOX
, platelet-type 12-lipoxygenase
, platelet-type lipoxygenase 12
, arachidonate 12-lipoxygenase
, LOW QUALITY PROTEIN: arachidonate 12-lipoxygenase, 12S-type