anti-EGLN3 Antibodies

72 Egl Nine Homolog 3 (C. Elegans) (EGLN3) Antibodies from 15 manufacturers are available on www.antibodies-online.com.

Data Quality
  • 14
Type
  • 72
    Primary
Antigen
  • 72
Reactivity
  • 64
  • 21
  • 14
  • 3
  • 3
Application
  • 56
  • 42
  • 26
  • 8
  • 4
Host
  • 57
  • 8
  • 7
Clonality
  • 67
  • 5
Clone
  • 2
  • 1
  • 1
Binding Specificity
  • 12
  • 9
  • 7
  • 7
  • 6
Conjugate
  • 43
  • 5
  • 5
  • 4
  • 3
  • 3
Isotype
  • 41
  • 3
  • 1
  • 1
  • 1
Format
  • 54
  • 6
Suggested next Filters
72 Products
ReactivityHuman
Application IF, WB
Order details Cat. No. ABIN530188
$440.00
50 μg
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
ReactivityHuman, Mouse (Murine)
Application IHC (p), WB
Order details Cat. No. ABIN6654127
$479.88
100 μg
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityHuman
Application ELISA, WB
Order details Cat. No. ABIN302149
$429.87
100 μg
Plus shipping costs $45.00
Delivery in 6 to 7 Business Days
ReactivityHuman, Mouse (Murine), Rat (Rattus)
Application WB
Order details Cat. No. ABIN631137
$517.86
50 μg
Plus shipping costs $45.00
Delivery in 9 to 11 Business Days
ReactivityHuman, Mouse (Murine), Rat (Rattus)
Application IHC, ELISA
Order details Cat. No. ABIN2422073
$493.90
Plus shipping costs $45.00
Delivery in 12 to 14 Business Days
ReactivityHuman
Application IHC (p), WB
Order details Cat. No. ABIN5534232
$550.00
400 μL
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityHuman
Application IHC, WB
Order details Cat. No. ABIN2997822
$590.93
Plus shipping costs $45.00
Delivery in 11 to 16 Business Days
ReactivityHuman
Application WB
Order details Cat. No. ABIN6139990
$393.25
Plus shipping costs $45.00
Delivery in 13 to 14 Business Days
ReactivityHuman
Application IHC, ELISA, WB
Order details Cat. No. ABIN2139718
$510.36
50 μL
Plus shipping costs $45.00
Delivery in 9 to 11 Business Days
ReactivityCow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Sheep (Ovine), Zebrafish (Danio rerio)
Application WB
Order details Cat. No. ABIN2784911
$229.00
100 μL
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityHuman
Application WB
Order details Cat. No. ABIN530189
$425.71
100 μg
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
ReactivityHuman
Application ELISA
Order details Cat. No. ABIN530190
$440.00
100 μg
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
ReactivityHuman
Application WB
Order details Cat. No. ABIN5577119
$460.00
100 μL
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
ReactivityHuman, Mouse (Murine), Rat (Rattus)
Application ELISA, WB
Order details Cat. No. ABIN2463514
$550.00
100 μL
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityHuman, Pig (Porcine), Rat (Rattus)
Application IHC, IHC (p), WB
Order details Cat. No. ABIN2599720
$639.83
50 μL
Plus shipping costs $45.00
Delivery in 11 to 14 Business Days
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EGLN3 Antigen Profile

Protein Summary

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.

Alternative names and synonyms associated with EGLN3

  • egl-9 family hypoxia-inducible factor 3 (egln3) antibody
  • egl-9 family hypoxia inducible factor 3 (EGLN3) antibody
  • egl-9 family hypoxia-inducible factor 3 L homeolog (egln3.L) antibody
  • egl-9 family hypoxia-inducible factor 3 (Egln3) antibody
  • 2610021G09Rik antibody
  • AI505553 antibody
  • AI648162 antibody
  • EGLN3 antibody
  • Hif-p4h-3 antibody
  • HIFP4H3 antibody
  • HIFPH3 antibody
  • PHD-3 antibody
  • Phd3 antibody
  • SM-20 antibody
  • wu:fj78a08 antibody
  • zgc:77019 antibody

Protein level used designations for EGLN3

Hif-p4h-3 , egl nine homolog 3 , phd3 , egl nine homolog 3 (C. elegans) , HIF-PH3 , HIF-prolyl hydroxylase 3 , HPH-3 , egl nine homolog 3, mitochondrial , factor-responsive smooth muscle protein , hypoxia-inducible factor prolyl hydroxylase 3 , prolyl hydroxylase domain-containing protein 3 , HIF prolyl hydroxylase 3 , HPH-1 , egl nine-like protein 3 isoform

GENE ID SPECIES
406602 Danio rerio
100145602 Xenopus (Silurana) tropicalis
100354210 Oryctolagus cuniculus
452850 Pan troglodytes
480286 Canis lupus familiaris
100219039 Taeniopygia guttata
100127282 Xenopus laevis
54702 Rattus norvegicus
423316 Gallus gallus
535578 Bos taurus
112407 Mus musculus
112399 Homo sapiens