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anti-Rat (Rattus) EGLN3 Antibodies:
anti-Mouse (Murine) EGLN3 Antibodies:
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Human Polyclonal EGLN3 Primary Antibody for EM, ICC - ABIN151073
Bai, Zeng, Hu, Li, Lin, Shang, Shi: Expression and characteristic of synthetic human epidermal growth factor (hEGF) in transgenic tobacco plants. in Biotechnology letters 2007
Show all 41 Pubmed References
Human Polyclonal EGLN3 Primary Antibody for ChIP, ICC - ABIN151769
Mikhaylova, Ignacak, Barankiewicz, Harbaugh, Yi, Maxwell, Schneider, Van Geyte, Carmeliet, Revelo, Wyder, Greis, Meller, Czyzyk-Krzeska: The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. in Molecular and cellular biology 2008
Show all 36 Pubmed References
Human Monoclonal EGLN3 Primary Antibody for IHC, IHC (p) - ABIN447479
Fujita, Gogate, Chiba, Toyama, Shapiro, Risbud: Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling. in The Journal of biological chemistry 2012
Show all 5 Pubmed References
Human Polyclonal EGLN3 Primary Antibody for ELISA, WB - ABIN409073
Nakayama, Gazdoiu, Abraham, Pan, Ronai: Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2. in The Biochemical journal 2006
comparative analysis of phd1 (show EGLN2 Antibodies), 2, and 3 expression in Xenopus laevis
we identified the beta2 adrenergic receptor (ADRB2 (show ADRB2 Antibodies)) as a downstream target for PHD3 in skeletal muscle
PHD2 (show EGLN1 Antibodies) and PHD3 are essential for normal kidney development as the combined inactivation of stromal PHD2 (show EGLN1 Antibodies) and PHD3 resulted in renal failure that was associated with reduced kidney size, decreased numbers of glomeruli, and abnormal postnatal nephron formation.
PHD3 could protect against cardiac perivascular fibrosis and improve myocardial function in an obstructive sleep apnea mouse model by inhibiting endothelial-to-mesenchymal transition.
PHD3 expression induced by cytokines is NF-kappaB (show NFKB1 Antibodies) dependent in mesangial cells. Endogenously produced NO further augments PHD3 expression via HIF-1 alpha (show HIF1A Antibodies).
Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages
PHD3 loss in cancer enables metabolic reliance on fatty acid oxidation via deactivation of ACC2 (show ACACB Antibodies).
Our observations disclose a novel role of PHD3 in the development of Tregs.
Epo (show EPO Antibodies) transcription in brain pericytes was HIF-2 dependent and cocontrolled by PHD2 (show EGLN1 Antibodies) and PHD3, oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regulate HIF activity.
deleting Phd1 (show EGLN2 Antibodies)-3 genes in osteoblasts increased osteoclast formation in vitro and in bone.
PHD3 is an active participant in atherogenesis
PHD3 overexpression may reduce the migratory and invasive capacity of gastric cancer cells, and inhibit the formation of tumor vasculature via negatively regulating HIF1A (show HIF1A Antibodies), which has been revealed to control VEGF (show VEGFA Antibodies) transcription.
provides a rationale for targeting the PHD3-mediated regulation of the adaptive cellular hypoxic response in MM and suggests that targeting the O2-sensing pathway, alone or in combination with other anti-myeloma chemotherapeutics, may have clinical efficacy
These results indicate that the immunohistochemistry analysis of the protein expression of PDK1 (show PDK1 Antibodies), PHD3, and HIF-1alpha (show HIF1A Antibodies) defines the hypoxic status of Neuroblastoma (show ARHGEF16 Antibodies) tumors.
These findings indicate that downregulation of PHD3 and FIH (show CASR Antibodies) in HCC (show FAM126A Antibodies) is associated with more aggressive tumor behavior and a poor prognosis in hepatocellular carcinoma
demonstrate that downregulation of PHD3 augments metastatic spread in human colorectal cancer and identify MCL-1 (show MCL1 Antibodies) as a novel downstream effector of oxygen sensing
In pancreatic Beta cells, knock-down of PHD3 inhibited glucose-stimulated insulin (show INS Antibodies) secretion.
Loss of PHD3 expression is associated with breast cancer.
The selective efficacy of PZ was further demonstrated at the cellular level by observing inhibition of the PHD3-dependent DNA damage response pathway without stabilization of HIF-1alpha (show HIF1A Antibodies).
The enhanced expression of PHD3 might likely contribute to the poor neovascularization and affect the biological characterization in PDAC cancer cells
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.
, egl nine homolog 3
, egl nine homolog 3 (C. elegans)
, HIF-prolyl hydroxylase 3
, egl nine homolog 3, mitochondrial
, factor-responsive smooth muscle protein
, hypoxia-inducible factor prolyl hydroxylase 3
, prolyl hydroxylase domain-containing protein 3
, HIF prolyl hydroxylase 3
, egl nine-like protein 3 isoform