Browse our anti-Coagulation Factor III (thromboplastin, Tissue Factor) (F3) Antibodies

Human Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

1. The interaction between tissue factor and filamin A (show FLNA Antibodies) is dependent on the differential phosphorylation of Ser253 and Ser258. The interaction with filamin A (show FLNA Antibodies) may translocate cell surface TF to cholesterol-rich lipid rafts, increasing cell surface TF activity as well as TF incorporation and release into microvesicles.

2. The induction of TG by BXPC3 cells was mainly driven by the TF pathway while TG generation triggered by MCF7 cells was also driven by FXII (show F12 Antibodies) activation.

3. Our study identifies a previously undescribed role of miRNA in venous thrombosis by regulating TF expression. Therefore, restoration of miR (show MLXIP Antibodies)-145 levels may serve as a promising therapeutic strategy for management of venous thrombosis

4. HUVEC and adult human dermal blood endothelial cells respond similarly to TNFalpha (show TNF Antibodies) and IL-1beta (show IL1B Antibodies) in terms of TF expression, and both are suitable models to examine cell surface TF activity and TF-positive microvesicle release in endothelial cells.

5. uPAR (show PLAUR Antibodies) and TF could potentially be attractive targets for molecular imaging and therapy in oral squamous cell carcinoma due to high positive expression rates and tumor-specific expression patterns.

6. The highest tissue factor activity was detected in microparticles from monocytes, lower activity - in microparticles from endothelial cells and THP-1 (show GLI2 Antibodies) cells, and no activity - in microparticles from platelets and granulocytes.

7. Patients with early onset preeclampsia are characterised by an attenuated coagulation response characterised by reduced thrombin (show F2 Antibodies) generation stimulated by low-dose TF and elevated plasma TFPI (show TFPI Antibodies) activity.

8. The proinflammatory cytokine IL-33 (show IL33 Antibodies) induces differential tissue factor expression and activity in monocyte subsets, as well as the release of procoagulant microvesicless. In this manner, IL-33 (show IL33 Antibodies) may contribute to the formation of a prothrombotic state characteristic for cardiovascular disease.

9. Pin1 (show PIN1 Antibodies) is a fast-acting enzyme which may be utilised by cells to protect the phosphorylation state of TF in activated cells prolonging TF activity and release, and therefore ensuring adequate haemostasis.

10. Circulating pentraxin nCRP has little pro-angiogenic effect but when dissociated into mCRP on the surface of endothelial cells it is able to trigger potent proangiogenic effects by inducing F3-gene upregulation and TF signaling.

Zebrafish Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

Mouse (Murine) Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

1. Tissue factor cytoplasmic domain is involved in TF-PAR-2 (show F2RL1 Antibodies) signalling initiating hepatic fibrosis and is a potential therapeutic target, as its deletion would not impact coagulation.

2. Myeloid cell derived tissue factor dampens inflammation in acid-induced acute lung injury.

3. Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression. Ticagrelor reduced TNF-alpha (show TNF Antibodies)-induced TF expression via proteasomal degradation.

4. Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 (show ARF6 Antibodies) trafficking.

5. Evening primrose oil and forskolin decreased the prothrombotic effect of celecoxib initiated by a LPS (show TLR4 Antibodies) challenge in mice, and this effect was, at least partly, mediated by mitigating TF expression and activity.

6. Thrombin (show F2 Antibodies)-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.

7. These findings reveal a novel biological function and mechanism of the protein C (show PROC Antibodies) pathway in which protein S and the aPC (show APC Antibodies)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Antibodies) in the context of endotoxemia and infection

8. Lung epithelial tissue factor regulates alveolar procoagulant activity and permeability in acute lung injury.

9. PGE2 increases both TF expression and activity through the regulation of the EP1 (show PTGER1 Antibodies)/SIRT1 (show SIRT1 Antibodies) pathway.

10. Fas (show FAS Antibodies)-initiated, caspase-3 (show CASP3 Antibodies)-dependent hepatocyte apoptosis increases tissue factor procoagulant activity through a mechanism involving phosphatidylserine externalization.

Pig (Porcine) Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

1. Tissue factor expression on porcine neonatal islet cell clusters is an important initiator of instant blood-mediated inflammatory reaction in islet xenotransplantation.

2. Prolonged clopidogrel treatment reduced coronary tissue factor (TF) expression and tended to reduce the blood TF level post-PCI (show SERPINA5 Antibodies), thus possibly modulating the risk of late thrombosis.

3. Procoagulant porcine tissue factor is induced in primary pig aortic endothelial cells only by fresh human plasma, and not by heat-inactivated plasma.

4. myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 (show CCL2 Antibodies) and CRP (show CRP Antibodies)

Rabbit Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

1. Arterial (18)F-fluorodeoxyglucose uptake reflects balloon catheter-induced thrombus formation and tissue factor expression via nuclear factor-kappaB in rabbit atherosclerotic lesions.

2. Polycations could present a new class of anticoagulants with such unique upstream downregulation of blood coagulation, selectively blocking tissue factor-dependent factor VII (show TH Antibodies) activation.

3. Upregulated TF expression and increased plasma TF level during reperfusion period, reduced plasma TFPI-1 (show TFPI Antibodies) level during reperfusion period.

4. lectin-like oxidized LDL receptor (show OLR1 Antibodies) Oxidized low-density lipoprotein receptor (show LDLR Antibodies) 1expression appears to be closely associated with tissue factor expression, apoptotic events and morphological vulnerability in atherosclerotic lesions