Browse our anti-Coagulation Factor III (thromboplastin, Tissue Factor) (F3) Antibodies

Human Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

1. Smad2 knockdown resulted in no inhibitory effect, whereas Smad3 knockdown completely suppressed TGF-beta-induced TF expression.

2. S. aureus-induced coagulation in human whole blood was mainly attributable to C5a-induced mRNA upregulation, monocyte tissue factors expression, and plasma TF activity.

3. A subset of extracellular vesicles in human saliva expose coagulant TF and CD24, a ligand of P-selectin, and may promote hemostasis by delivering coagulant tissue factor to activated platelets.

4. Effect of Smoking Status on Monocyte Tissue Factor Activity, Carotid Atherosclerosis and Long-Term Prognosis in Metabolic Syndrome.

5. The simultaneous increase of TF concentration and activity, VEGF-A in the blood of patients with Essential Thrombocythemia, as well as a positive correlation between the concentration of TF and VEGF-A demonstrates the coexistence of TF-dependent coagulation and activation of angiogenesis.

6. Neutrophil extracellular traps promote endothelial cell activation and increased thrombogenicity through concerted action of IL-1alpha and cathepsin G and tissue factor production.

7. Under venous flow, fibrinogen continually penetrates the clot, and gamma'-fibrin regulates thrombin in tissue factor driven coagulation.

8. High tissue factor expression is associated with hepatocellular carcinoma.

9. Androgen receptor is crucial for dampening prostate tissue factor expression via nuclear factor-kappaB and early growth response protein 1 pathway.

10. under flow, TFPI-alpha is capable to antagonize fibrin formation in a manner dependent on and restricted by local TF/factor VIIa and factor Xa activities

11. he results demonstrated that CDCA and apoM may modulate TF isoforms in different cell lines, and suggested that asTF may serve a role in the pathophysiological mechanism underlying cervical cancer development. In conclusion, the TF isoforms serve important and distinct roles in pathophysiological processes

12. Higher TF activities are present in thinner abdominal aortic aneurysm regions. These parameters and local fibrinolysis may be part of the processes leading to destruction of the aneurysm wall.

13. The majority of plasma samples from burn patients have active FXIa and FIXa, with a significant fraction of them having active TF. The concentration of all three proteins varies in a wide range.

14. Alternatively spliced tissue factor levels are elevated in the plasma of patients with chronic liver diseases.

15. Increased plasma concentrations of TF in atrial fibrillation (AF) patients are accompanied and probably at least partly explained by increased levels of TF-bearing extracellular vesicles, which may be mechanistically involved in increased thrombogenicity in AF patients.

16. In diabetics, miR-19a and miR-126 cooperate to exhibit anti-thrombotic properties by epigenetic regulation of tissue factor.

17. High levels of TF were associated with thrombosis related to antiphospholipid syndrome.

18. Elevated plasma levels of procoagulant factors, such as FVIII or prothrombin, enhanced thrombin generation and reduced the amount of TF required for the initiation of thrombin formation.

19. TF knockout in MDA-MB-231cells reduced TF/FVIIa signaling and coagulation activity. Silencing of TF in MDA-MB-231cells decreased the release of microvesicles.

20. Subjects with AG and GG genotype had significantly higher TF levels than AA genotype. GG genotype of 603A>G polymorphism augments the risk of thrombosis by 4.4 fold, thus highlighting the significance of this polymorphism in the development of DVT

Zebrafish Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

1. f3b is required for brain vascular development and for development of part of the somatic vasculature during embryogenesis in the zebrafish

Mouse (Murine) Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

1. Sirt3 loss-of-function enhances experimental thrombosis in vivo via an increase of neutrophil extracellular traps and elevation of TF suggesting thrombo-protective effects of endogenous Sirt3.

2. Androgen receptor is crucial for dampening prostate tissue factor expression via nuclear factor-kappaB and early growth response protein 1 pathway.

3. We conclude that brain TF plays an important role in localization of hemorrhage and also regulates cerebrospinal fluid flow under normal conditions

4. Tissue factor cytoplasmic domain is involved in TF-PAR-2 signalling initiating hepatic fibrosis and is a potential therapeutic target, as its deletion would not impact coagulation.

5. Myeloid cell derived tissue factor dampens inflammation in acid-induced acute lung injury.

6. Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression. Ticagrelor reduced TNF-alpha-induced TF expression via proteasomal degradation.

7. Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.

8. Evening primrose oil and forskolin decreased the prothrombotic effect of celecoxib initiated by a LPS challenge in mice, and this effect was, at least partly, mediated by mitigating TF expression and activity.

9. There was no significant contribution of TF on myeloid cells in multiple models of experimental ALI, leading to the conclusion that TF in myeloid cells is not a major contributor to experimental ALI.

10. Hepatocyte TF activates coagulation in a mouse model of chronic liver injury

11. Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.

12. expression by myeloid cells affects macrophage differentiation, and regulate Mycobacterium tuberculosis growth

13. TF expressed on tumor microparticles contributes to the increased incidence of cancer-associated venous thrombosis in mice in vivo.

14. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC in the context of endotoxemia and infection

15. Lung epithelial tissue factor regulates alveolar procoagulant activity and permeability in acute lung injury.

16. PGE2 increases both TF expression and activity through the regulation of the EP1/SIRT1 pathway.

17. Fas-initiated, caspase-3-dependent hepatocyte apoptosis increases tissue factor procoagulant activity through a mechanism involving phosphatidylserine externalization.

18. Heme promotes tissue factor-dependent coagulation activation and induces tissue factor expression on leukocytes in vivo.

19. TF is essential for the development of pericyte coverage of tumor microvessels and aPL-induced tumor cell expression of chemokine ligand 2, a mediator of pericyte recruitment

20. Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor signaling.

Pig (Porcine) Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

1. Tissue factor expression on porcine neonatal islet cell clusters is an important initiator of instant blood-mediated inflammatory reaction in islet xenotransplantation.

2. Prolonged clopidogrel treatment reduced coronary tissue factor (TF) expression and tended to reduce the blood TF level post-PCI, thus possibly modulating the risk of late thrombosis.

3. Procoagulant porcine tissue factor is induced in primary pig aortic endothelial cells only by fresh human plasma, and not by heat-inactivated plasma.

4. myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP

Rabbit Coagulation Factor III (thromboplastin, Tissue Factor) (F3) interaction partners

1. Arterial (18)F-fluorodeoxyglucose uptake reflects balloon catheter-induced thrombus formation and tissue factor expression via nuclear factor-kappaB in rabbit atherosclerotic lesions.

2. Polycations could present a new class of anticoagulants with such unique upstream downregulation of blood coagulation, selectively blocking tissue factor-dependent factor VII activation.

3. Upregulated TF expression and increased plasma TF level during reperfusion period, reduced plasma TFPI-1 level during reperfusion period.

4. Prolonged expression of biologically active rabbit TF was shown within jugular vein grafts of hypercholesterolemic rabbits.

5. lectin-like oxidized LDL receptor Oxidized low-density lipoprotein receptor 1expression appears to be closely associated with tissue factor expression, apoptotic events and morphological vulnerability in atherosclerotic lesions