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This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.
NACHT, leucine rich repeat and PYD containing 12
, NLR family, pyrin domain containing 12
, PYRIN-containing APAF1-like protein 7
, NACHT, LRR and PYD domains-containing protein 12
, NLR family, pyrin domain containing 12, isoform 2
, monarch 1
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12
, regulated by nitric oxide
, NACHT, LRR and PYD containing protein 12