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Full name:: Programmed Cell Death 6 Proteins (PDCD6)

On www.antibodies-online.com are 10 Programmed Cell Death 6 (PDCD6) Proteins from 0 different suppliers available. A total of 93 PDCD6 products are currently listed.

Synonyms:: alg-2, Alg2, AV299538, MA-3, MGC52821, MGC132114, PDCD6, PEF1B, PS2, zgc:63952

list all proteins	Gene Name	GeneID	UniProt
Human PDCD6	PDCD6	10016	O75340
Mouse PDCD6	PDCD6	18570	P12815
Rat PDCD6	PDCD6	308061
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Relevant Pathways for PDCD6 Proteins

Positive Regulation of Endopeptidase Activity

More product categories related to PDCD6 Protein

More Proteins for PDCD6 Interaction Partners

Human Programmed Cell Death 6 (PDCD6) interaction partners

ALG-2 binding to Scotin (show SHISA5 Proteins) is strictly calcium dependent, indicating a role of this interaction in calcium signaling pathways
Ca2 (show CA2 Proteins)+-loaded ALG-2 bridges Alix (show PDCD6IP Proteins) and TSG101 (show TSG101 Proteins) as an adaptor protein.
found that targeting Requiem and Alg-2 did not result in extended culture viability, but resulted in an increase in maximum viable cell numbers and cumulative IVCD under fed-batch conditions
inability of the two-residue shorter ALG-2 isoform to bind Alix (show PDCD6IP Proteins)
the alg2 binding site is one of the key determinants of the retention kinetics of Sec31A (show SEC31A Proteins) at endoplasmic reticulum exit sites
This is the first report showing interaction of ALG-2 with a P-body component (PATL1 (show PATL1 Proteins)).PATL1 (show PATL1 Proteins) as well as DCP1A (show DCP1A Proteins), a well-known P-body marker, co-localized with a subset of ALG-2.
The results of in vitro binding assays using purified recombinant proteins indicated that ALG-2 functions as a Ca(2 (show CA2 Proteins))-dependent adaptor protein that bridges ALIX (show PDCD6IP Proteins) and ESCRT-I (show VPS28 Proteins) to form a ternary complex
ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A (show SEC31A Proteins) complex.
Lack of ALG-2, ALIX (show PDCD6IP Proteins) or Vps4B (show vps4b Proteins) each prevents shedding, and repair of the injured cell membrane
Results show the crystal structure of the complex between ALG-2 and a peptide of Sec31A (show SEC31A Proteins) and found that the peptide binds to the third hydrophobic pocket (Pocket 3) and that ALG-2 recognizing 2 types of motifs at different hydrophobic surfaces of Sec31A (show SEC31A Proteins).

Mouse (Murine) Programmed Cell Death 6 (PDCD6) interaction partners

ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity.
Substitution of either L52 with Ala or F148 with Ser (show SIGLEC1 Proteins) of ALG-2 caused loss of binding abilities to PLSCR3 (show PLSCR3 Proteins) lacking type 1 motif but retained those to PLSCR3 (show PLSCR3 Proteins) lacking type 2 motif
ALG-2 is physiologically dispensable for apoptotic responses (ALG-2 protein)

PDCD6 Protein Profile

Protein Summary

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.

Alternative names and synonyms associated with PDCD6

programmed cell death 6 L homeolog (pdcd6.L)
programmed cell death 6 (pdcd6)
programmed cell death 6 (PDCD6)
programmed cell death 6 (Pdcd6)

alg-2 protein
Alg2 protein
AV299538 protein
MA-3 protein
MGC52821 protein
MGC132114 protein
PDCD6 protein
PEF1B protein
PS2 protein
zgc:63952 protein

Protein level used designations for PDCD6

programmed cell death 6 , programmed cell death protein 6 , apoptosis-linked gene 2 protein , probable calcium-binding protein ALG-2 , ALG-257 , PMP41

GENE ID	SPECIES
380264	Xenopus laevis
393925	Danio rerio
723039	Macaca mulatta
10016	Homo sapiens
18570	Mus musculus
420988	Gallus gallus
609549	Canis lupus familiaris
100125927	Bos taurus
308061	Rattus norvegicus

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