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Full name:: Programmed Cell Death 6 Proteins (PDCD6)

On www.antibodies-online.com are 11 Programmed Cell Death 6 (PDCD6) Proteins from 8 different suppliers available. Additionally we are shipping PDCD6 Antibodies (79) and PDCD6 Kits (7) and many more products for this protein. A total of 99 PDCD6 products are currently listed.

Synonyms:: alg-2, Alg2, AV299538, MA-3, MGC52821, MGC132114, PDCD6, PEF1B, PS2, zgc:63952

list all proteins	Gene Name	GeneID	UniProt
	PDCD6	10016	O75340
	PDCD6	18570	P12815
Rat PDCD6	PDCD6	308061
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PDCD6 Proteins (PDCD6) by Origin

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Relevant Pathways for PDCD6 Proteins

Positive Regulation of Endopeptidase Activity

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Human Programmed Cell Death 6 (PDCD6) interaction partners

MAP1B (show MAP1B Proteins) heavy chain has a unique binding site for a calcium-binding protein (show CETN1 Proteins) ALG-2.
These results suggest that a change in the intracellular calcium level plays a role in regulation of the secretory pathway via interaction of ALG-2 with MISSL and MAP1B (show MAP1B Proteins).
The gene copy numbers and mRNA levels for both ALG-2 and HEBP2 (show HEBP2 Proteins) are significantly upregulated in breast and lung cancer. Coexpression of ALG-2 and HEBP2 (show HEBP2 Proteins) markedly increases the cytoplasmic pool of ALG-2 and alters the subcellular distribution of HEBP2 (show HEBP2 Proteins). Abnormalities in the ALG-2/HEBP2 (show HEBP2 Proteins) interaction impairs spindle orientation and positioning during mitosis.
The results suggest that ALG-2 acts as a Ca2 (show CA2 Proteins)+-sensitive adaptor to concentrate and polymerize TFG at endoplasmic reticulum exit sites, supporting a potential role for ALG-2 in COPII-dependent trafficking from the endoplasmic reticulum.
ALG2 has a tumor suppressive role in glioblastoma and might be a potential target for the treatment of glioblastoma.
miR (show MLXIP Proteins)-183 may function as an oncogene (show RAB1A Proteins) and may enhance cell proliferation by targeting PDCD6, implying a potential therapeutic target for this malignancy.
Our results suggest that PDCD6 may play an important role in the pathogenesis of cervical squamous cell carcinoma
PDCD6 may represent a biomarker candidate gene that could help to identify a group of patients at high risk for recurrence and death.
Palmitoylation sites and the N-terminal Pro-rich region were necessary for efficient secretion, but ABSs (ALG-2-binding sites) were dispensable.
The present study provided evidence that rs4957014 and rs3756712 are associated with Uterine leiomyoma (UL) risk, the results indicated that genetic polymorphisms in PDCD6 may contribute to the development of UL.

Mouse (Murine) Programmed Cell Death 6 (PDCD6) interaction partners

ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity.
Substitution of either L52 with Ala or F148 with Ser (show SIGLEC1 Proteins) of ALG-2 caused loss of binding abilities to PLSCR3 (show PLSCR3 Proteins) lacking type 1 motif but retained those to PLSCR3 (show PLSCR3 Proteins) lacking type 2 motif
ALG-2 is physiologically dispensable for apoptotic responses (ALG-2 protein)

PDCD6 Protein Profile

Protein Summary

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.

Alternative names and synonyms associated with PDCD6

programmed cell death 6 L homeolog (pdcd6.L)
programmed cell death 6 (pdcd6)
programmed cell death 6 (PDCD6)
programmed cell death 6 (Pdcd6)

alg-2 protein
Alg2 protein
AV299538 protein
MA-3 protein
MGC52821 protein
MGC132114 protein
PDCD6 protein
PEF1B protein
PS2 protein
zgc:63952 protein

Protein level used designations for PDCD6

programmed cell death 6 , programmed cell death protein 6 , apoptosis-linked gene 2 protein , probable calcium-binding protein ALG-2 , ALG-257 , PMP41

GENE ID	SPECIES
380264	Xenopus laevis
393925	Danio rerio
723039	Macaca mulatta
10016	Homo sapiens
18570	Mus musculus
420988	Gallus gallus
609549	Canis lupus familiaris
100125927	Bos taurus
308061	Rattus norvegicus

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