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Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
deleted in U twenty twenty
, roundabout homolog 1
, roundabout (axon guidance receptor, Drosophila) homolog 1
, roundabout, axon guidance receptor, homolog 1 (Drosophila)
, Roundabout1 protein
, roundabout 1
, roundabout, axon guidance receptor, homolog 1
, roundabout homolog 1-like