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These results demonstrate a key role for Robo-Slit signaling in vertebrate longitudinal axon guidance; Robo1 and Robo3 (show ROBO3 Proteins) restricted the extent of defasciculation of the tract of the postoptic commissure.
While Slit1 (show SLIT1 Proteins) and Robo2 (show ROBO2 Proteins) are only expressed in peripheral axons and their cell bodies, Slit2 (show SLIT2 Proteins), Slit3 (show SLIT3 Proteins) and Robo1 are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves.
restoration of miR (show MLXIP Proteins)-218 inhibited retinal angiogenesis via targeting Robo1. MiR (show MLXIP Proteins)-218 contributed to the inhibition of retinal angiogenesis and miR (show MLXIP Proteins)-218 might be a new therapeutic target for preventing retinal neovascularization..
Robo1-Slit2 interaction required for pathfinding mechanism essential to establish the functionally important habenulo-interpeduncular connection.
FLRT3 (show FLRT3 Proteins) is a Robo1 coreceptor in developing axons.
Slit2 (show SLIT2 Proteins)/Robo1 signaling promotes intestinal tumorigenesis through Src (show SRC Proteins)-mediated activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice
Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide production upon exposure to air.
Slit2 (show SLIT2 Proteins) signaling through Robo1 and Robo2 (show ROBO2 Proteins) has a role in retinal neovascularization
Data indicate the roles of Slit1 (show SLIT1 Proteins)/Robo1 and Netrin1/DCC (show DCC Proteins) signals in positioning motor neuron cell bodies.
This study demonistrated that significant increase of interneurons in the cortices of Robo1-/- mice, implicate Robo1 in the regulation of progenitor cell dynamics in the developing forebrain.
The alteration of Slit2 (show SLIT3 Proteins) and Robo1 expression in the retinas of diabetic rats and patients with proliferative diabetic retinopathy suggests a role for the Slit-Robo signal in the various stages diabetic retinopathy.
Results demonstrate that human ROBO1 may be involved in the regulation of the structure and connectivity of posterior part of corpus callosum.
ROBO1 gene mutation is responsible for the development of pituitary stalk interruption syndrome.
human placental multipotent mesenchymal stromal cell express Slit2 (show SLIT3 Proteins) and both Robo1 and Robo4 (show ROBO4 Proteins) are present in human umbilical vein endothelial cells.
Slit2 (show SLIT3 Proteins)-Robo1 signaling promoted the adhesion, invasion and migration of tongue carcinoma cells by upregulating the expression levels of MMP2 (show MMP2 Proteins) and MMP9 (show MMP9 Proteins) and, downregulating the expression of E-cadherin (show CDH1 Proteins).
High Slit2 expression is associated with glioma.
ROBO1 mediated the inhibitory effect of miR (show MLXIP Proteins)-218 on angiogenesis in gastric cancer.
Results indicate the importance of SLIT2 (show SLIT3 Proteins)-ROBO1-CDC42 (show CDC42 Proteins) signaling pathway in predicting tumor progression.
We postulate that Robo1 promotes tumor invasion partly by the upregulation of MMP2 (show MMP2 Proteins) after activation of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway. Notably, Slit2 (show SLIT3 Proteins) knockdown caused the upregulation of Robo1 expression both at the mRNA and protein levels. Thus, the stimulatory effects of Slit2 (show SLIT3 Proteins) knockdown on tumor progression can be ascribed, at least in part, to the upregulation of Robo1 and its positive role in tumor progression.
ROBO1 deletion in a putative transcriptional regulatory region
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
deleted in U twenty twenty
, roundabout homolog 1
, roundabout (axon guidance receptor, Drosophila) homolog 1
, roundabout, axon guidance receptor, homolog 1 (Drosophila)
, Roundabout1 protein
, roundabout 1
, roundabout, axon guidance receptor, homolog 1
, roundabout homolog 1-like
, magic roundabout
, divalent metal transporter-1
, protein RoBo-1
, rodent bone protein