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the human AACS promoter is a PPARgamma target gene and this nuclear receptor is recruited to the AACS promoter by direct interaction with Sp1
These results suggest that Sp1 regulates gene expression of AACS in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.
Cleavage of AACS by legumain is critical for the regulation of enzymatic activity and results in gain-of-function changes.
Knockdown of AACS inhibits differentiation of 3T3-L1 adipocytes and suppresses expression of the adipocyte markers, peroxisome proliferator-activated receptor gama and CCAAT/enhancer binding protein alpha.
Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels.
These results suggest that AACS is regulated by SREBP-2 and involves in the normal development of neurons.
AACS promoter activity was controlled mainly by C/EBPalpha during adipogenesis.
Activates acetoacetate to acetoacetyl-CoA (By similarity).
, acetoacetyl-CoA synthetase
, acetoacetyl-CoA synthetase-like
, acetoacetyl-coa synthetase
, acetoacetate-CoA ligase
, acyl-CoA synthetase family member 1
, homolog of C. elegans supressor of ras 5 (sur-5)
, protein sur-5 homolog
, AcAc-CoA ligase
, acetoacetyl-CoA ligase