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the human AACS promoter is a PPARgamma (show PPARG Proteins) target gene and this nuclear receptor is recruited to the AACS promoter by direct interaction with Sp1 (show PSG1 Proteins)
These results suggest that Sp1 (show SP1 Proteins) regulates gene expression of AACS in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.
Cleavage of AACS by legumain (show LGMN Proteins) is critical for the regulation of enzymatic activity and results in gain-of-function changes.
Knockdown of AACS inhibits differentiation of 3T3-L1 adipocytes and suppresses expression of the adipocyte markers, peroxisome proliferator-activated receptor (show PPARG Proteins) gama and CCAAT/enhancer binding protein alpha (show CEBPA Proteins).
Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 (show SREBF2 Proteins) and affects serum cholesterol levels.
These results suggest that AACS is regulated by SREBP-2 (show SREBF2 Proteins) and involves in the normal development of neurons.
AACS promoter activity was controlled mainly by C/EBPalpha (show CEBPA Proteins) during adipogenesis.
Activates acetoacetate to acetoacetyl-CoA (By similarity).
, acetoacetyl-CoA synthetase
, acetoacetyl-CoA synthetase-like
, acetoacetyl-coa synthetase
, acetoacetate-CoA ligase
, acyl-CoA synthetase family member 1
, homolog of C. elegans supressor of ras 5 (sur-5)
, protein sur-5 homolog
, AcAc-CoA ligase
, acetoacetyl-CoA ligase