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The authors conclude that the TRC40 pathway is critical for hearing and propose that otoferlin (show OTOF ELISA Kits) is an essential substrate of this pathway in hair cells.
Asna1/TRC40 is required at a late step of herpes simplex virus type 1 infection for efficient release of mature virions to the extracellular milieu.
reveal unanticipated complexity in the mutual regulation of the TRC40 receptor subunits and raise the question as to the role of the excess CAML (show CAMLG ELISA Kits) in the endoplasmic reticulum
Emerin (show EMD ELISA Kits) interacts with TRC40 in situ.
The repertoire of VAPB (show VAPB ELISA Kits) interactors is more diverse than previously anticipated and link VAPB (show VAPB ELISA Kits) to the function of ATPase (show DNAH8 ELISA Kits) complexes such as p97 (show EIF4G2 ELISA Kits)/FAF1 (show FAF1 ELISA Kits) and ASNA1/transmembrane-domain recognition complex.
Proteins bind to TRC40 and can utilise this component for their delivery to the ER membrane.
PEX19 (show PEX19 ELISA Kits) formed a complex with the peroxisomal tail anchored protein PEX26 (show PEX26 ELISA Kits) in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway.
Results indicate calcium-modulating cyclophilin ligand (CAML (show CAMLG ELISA Kits)) and WRB (show WRB ELISA Kits) as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells.
Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2 (show CA2 ELISA Kits)+ sensor calneurons requires the TRC40/Asna1 protein chaperone.
The coiled-coil domain of WRB (show WRB ELISA Kits) is the binding site for TRC40/Asna1.
Asna1 ensures retrograde transport and ER and insulin (show INS ELISA Kits) homeostasis in beta-cells. Asna1 KO mice develop hypoinsulinemia, impaired insulin (show INS ELISA Kits) secretion, and glucose intolerance that rapidly progresses to overt diabetes.
These findings indicate that Asna1 plays a crucial role during early embryonic development.
Data show that the parental gene, asna-1, was not targeted by miR (show MYLIP ELISA Kits)-249, presumably because asna-1 is involved in insulin (show INS ELISA Kits) secretion; the cleavage of the asna-1 mRNA might be so detrimental and could be under selective pressure to escape miR (show MYLIP ELISA Kits)-249 targeting.
findings show that worms lacking activity of the asna-1 gene arrest growth reversibly at the L1 stage even when food is abundant; proposed that ASNA1 is an evolutionarily conserved modulator of insulin (show INS ELISA Kits) signaling
As(III)- & Sb(III)-stimulated ArsA (show ARSA ELISA Kits) ATPase (show DNAH8 ELISA Kits) activities are not restricted to bacteria. asna-1 gene from C. elegans encodes functional ArsA (show ARSA ELISA Kits) ATPase (show DNAH8 ELISA Kits) whose activity is stimulated by As(III) & Sb(III), which is critical for As(III) & Sb(III) tolerance.
This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion.
, arsenical pump-driving ATPase
, arsenite-stimulated ATPase
, golgi to ER traffic 3 homolog
, transmembrane domain recognition complex 40 kDa ATPase subunit
, transmembrane domain recognition complex, 40kDa
, arsenical pump-driving atpase
, ATPase Asna1
, arsenite-translocating ATPase
, arsA arsenite transporter, ATP-binding, homolog 1
, ATPase asna1
, arsenical resistance ATPase
, arsenite-transporting ATPase
, arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
, Arsenical pump-driving ATPase
, Arsenical resistance ATPase
, Arsenite-translocating ATPase
, Arsenite-transporting ATPase
, arsA arsenite transporter, ATP-binding homolog 1
, ATPase ASNA1-like