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The authors conclude that the TRC40 pathway is critical for hearing and propose that otoferlin is an essential substrate of this pathway in hair cells.
Asna1/TRC40 is required at a late step of herpes simplex virus type 1 infection for efficient release of mature virions to the extracellular milieu.
reveal unanticipated complexity in the mutual regulation of the TRC40 receptor subunits and raise the question as to the role of the excess CAML in the endoplasmic reticulum
Emerin interacts with TRC40 in situ.
The repertoire of VAPB interactors is more diverse than previously anticipated and link VAPB to the function of ATPase complexes such as p97/FAF1 and ASNA1/transmembrane-domain recognition complex.
Proteins bind to TRC40 and can utilise this component for their delivery to the ER membrane.
PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway.
Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells.
Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone.
The coiled-coil domain of WRB is the binding site for TRC40/Asna1.
Asna1 is required for efficient histocompatibility (HLA) class I downregulation mediated by viral protein BNLF2a.
Asna1 can mediate membrane insertion of RAMP4 and Sec61beta without the participation of other cytosolic proteins by a mechanism that depends on the presence of ATP or ADP and a protease-sensitive receptor in the endoplasmic reticulum membrane.
Human ASNA1 is highly expressed in pancreatic beta cells, but not in other pancreatic endocrine cell types, and regulates insulin secretion in cultured cells.
TRC40/Asna-1 interacts posttranslationally with tail-anchored proteins in a transmembrane domain-dependent manner for delivery to a proteinaceous receptor at the endoplasmic reticulum membrane.
the hydrophobicity of the TA region dictates whether a precursor is delivered to the ER via the Hsp40/Hsc70 or Asna-1/TRC40-dependent route.
ASNA1 is a target to overcome platinum resistance in ovarian cancer
These findings support a role for the Asna1 ATPase activity in ensuring the survival of pancreatic multipotent progenitor cells , possibly by counteracting p53-mediated apoptosis.
Asna1 ensures retrograde transport and ER and insulin homeostasis in beta-cells. Asna1 KO mice develop hypoinsulinemia, impaired insulin secretion, and glucose intolerance that rapidly progresses to overt diabetes.
These findings indicate that Asna1 plays a crucial role during early embryonic development.
Data show that the parental gene, asna-1, was not targeted by miR-249, presumably because asna-1 is involved in insulin secretion; the cleavage of the asna-1 mRNA might be so detrimental and could be under selective pressure to escape miR-249 targeting.
findings show that worms lacking activity of the asna-1 gene arrest growth reversibly at the L1 stage even when food is abundant; proposed that ASNA1 is an evolutionarily conserved modulator of insulin signaling
As(III)- & Sb(III)-stimulated ArsA ATPase activities are not restricted to bacteria. asna-1 gene from C. elegans encodes functional ArsA ATPase whose activity is stimulated by As(III) & Sb(III), which is critical for As(III) & Sb(III) tolerance.
This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion.
, arsenical pump-driving ATPase
, arsenite-stimulated ATPase
, golgi to ER traffic 3 homolog
, transmembrane domain recognition complex 40 kDa ATPase subunit
, transmembrane domain recognition complex, 40kDa
, arsenical pump-driving atpase
, ATPase Asna1
, arsenite-translocating ATPase
, arsA arsenite transporter, ATP-binding, homolog 1
, ATPase asna1
, arsenical resistance ATPase
, arsenite-transporting ATPase
, arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
, Arsenical pump-driving ATPase
, Arsenical resistance ATPase
, Arsenite-translocating ATPase
, Arsenite-transporting ATPase
, arsA arsenite transporter, ATP-binding homolog 1
, ATPase ASNA1-like