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The TAQ1A1 allele of the DRD2 gene region contributes to shortened years of survival in alcohol dependent individuals, along with age and gender.
Disruption of DRD2 promoted the proliferation of NSCLC cell lines by inhibiting the NF-kappaB (show NFKB1 Proteins) signaling pathway and overexpression not only blocked lipopolysaccharide-induced cell proliferation and growth, but also inhibited the tumorigenesis in murine xenograft models.
our results indicate a reduced natural-reward brain reactivity in smokers with the B1 allele of the DRD2 Taq1B polymorphism as evidenced with the approach-avoidance task.
The G allele of DRD2 rs1800497 SNP was associated with a significant risk reduction of awake-sleep bruxism (p = 0.041).
In a cohort of schizophrenia inpatients CYP2D6 (show CYP2D6 Proteins) metabolic activity affects mean AP daily dose only in the presence of DRD2 Taq1A polymorphic allele. CYP2D6 (show CYP2D6 Proteins) metabolic activity correlates independently from DRD2 Taq1A polymorphism with hospital stay duration. Subpopulation of schizophrenia inpatients with altered CYP2D6 (show CYP2D6 Proteins) activity (PMs (show PRB1 Proteins) and UMs (show TBX3 Proteins)) carriers of Taq1A polymorphisms needs special attention of clinicians in aligning o
association to the purified GHSR:D2R heteromer triggers a different active conformation of Galphai that is linked to a higher rate of GTP binding (show RND2 Proteins) and a faster dissociation from the heteromeric receptor.
crystal structure of DRD2 in complex with the widely prescribed atypical antipsychotic drug risperidone
childhood urbanicity and variation in dopamine genes COMT (show COMT Proteins), DRD1 (show DRD1 Proteins) and DRD2 alters adult prefrontal function as measured by fMRI
analysis of molecular dynamics simulations with a cumulative length of ~77 mus of D2R and D3R wild-type and their E2.65A mutants bound to SB269652
In schizophrenia patients, presence of DRD2 Taq 1 D2D2 and 5-HT2A C516T CT genotypes in patients were more likely to be associated with non-response to risperidone.
Studied a novel Dopamine Receptor 2 (DRD2) G/A SNP for resistance to fescue toxicosis.
DRD2 in primary mesencephalic neurons had a significant regulative effect on the adipogenesis genes.
Dopamine D2 receptor deletion from parvalbumin (show PVALB Proteins) interneurons in mouse causes an impaired inhibitory activity in the ventral hippocampus and a dysregulated dopaminergic system resulting in schizophrenia-like phenotypes.
boosting dopamine signaling in the striatum by acute cocaine administration reveals that absence of D2L, but not of D2S, strongly impairs the motor and cellular response to the drug, in a manner similar to the ablation of both isoforms. These results suggest that when the dopamine system is challenged, D2L signaling is required for the control of striatal circuits regulating motor activity.
This study explored the spatial distribution of D2 medium-sized spiny neurons across the rostral-caudal axis of the striatum using D2-eGFP double transgenic mice.
Pre- and postsynaptic colocalization of kappa opioid receptor (show OPRK1 Proteins) and D2R supports a role for kappa opioid receptor (show OPRK1 Proteins) potentiating both the D2R inhibitory autoreceptor function and the inhibitory action of D2R on efferent medium spiny neurons. Kappa opioid receptor (show OPRK1 Proteins) co-activation accelerates D2R sensitization by contributing to decrease dopamine release in the nucleus accumbens.
Study shows that social isolation to a series of schizophrenia-related deficits and that potential interactions among histidine triad nucleotide binding protein 1 (show HINT1 Proteins), NMDA receptor 1 (show GRIN1 Proteins), and dopamine receptor 2 may underlie the behavioral deficits induced by social isolation.
These results are in support of intrastriatal connections of D2R(+)-MSNs (iMSNs) with dMSNs and indicate that D2R signaling in MSNs is critical for the function of intrastriatal circuits.
Dopamine D2L isoform receptors and nucleus accumbens D2 receptor medium spiny neurons act to suppress the influence of previously correct behavioral strategies allowing transfer of behavioral control to new strategies.
Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC (show POMC Proteins)-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.
D2 receptor (D2R) +/+ enriched environment (EE) mice lived nearly 16% longer than their deprived environment (DE) counterparts.
Mapped associations occur between changes in D2 and D3 dopamine receptor (show DRD3 Proteins) occupancy and brain hemodynamics
These data provide evidence for a predisposition to self-administer cocaine based on dopamine D2 receptor availability, and demonstrate that the brain dopamine system responds rapidly following cocaine exposure.
The amount of dopamine d1 receptor (show DRD1 Proteins), dopamine D2 receptor, and follicle stimulating hormone receptor (show FSHR Proteins) mRNA were quantified in ovarian tissues in anestrous and mares expressing estrus during the breeding season are reported.
The pig DRD2 gene was cloned, investigated its distribution in tissues and polymorphisms were identified.
The increase in NOS protein seen in both the endothelium and vascular smooth muscle in response to cerebral vasospasm is enhanced by dopamine in a D(2)R-dependent mechanism.
Damb receptor uniquely activates Gq to mobilize Ca(2 (show CA2 Proteins)+) signaling with greater efficiency and dopamine sensitivity
Findings suggest a role for dopamine D1-like receptor (show DRD1 Proteins) Dop1R2 in the repression of genes that coordinate metamorphosis.
Results suggest that the activation state of DAMB protein contributes to oxidative stress susceptibility in Drosophila and lead to a proposed model for paraquat neurotoxicity.
Dopamine D2 receptor play role in memory consolidation.
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia\; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
D(2) dopamine receptor
, dopamine D2 receptor
, dopamine receptor D2 isoform
, seven transmembrane helix receptor
, D2 dopamine receptor
, Dopamine D2 receptor
, dopamine receptor D2b
, dopamine D2 receptor 2
, D2 receptor
, dopamine receptor 2
, D(2) dopamine receptor A
, D2R 1
, dopamine receptor D2
, dopamine receptor 2 protein
, D[]-like receptor
, dopamine receptor in mushroom bodies
, dopamine-2 receptor