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Human HIF1A ELISA Kit for Sandwich ELISA - ABIN414447
Lu, Jiang, Chen, Xu, Hu, Zhao, Gao, Guo: Lactate dehydrogenase 5 expression in Non-Hodgkin lymphoma is associated with the induced hypoxia regulated protein and poor prognosis. in PLoS ONE 2013
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Rat (Rattus) HIF1A ELISA Kit for Sandwich ELISA - ABIN416136
Chen, Pan, Liu, Chen, Liu, Yeh, Tsai, Young, Zhang, Chao: The effects and underlying mechanisms of S-allyl l-cysteine treatment of the retina after ischemia/reperfusion. in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2012
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Mouse (Murine) HIF1A ELISA Kit for Sandwich ELISA - ABIN424082
Du, Lin, Wang, Zhang, Wu, Lu, Ji, Yu: Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1? in tumor and normal cells. in Cancer chemotherapy and pharmacology 2011
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Human HIF1A ELISA Kit for Sandwich ELISA - ABIN366532
Jiang, Tang, Guo, Jiao: The role of insulin-like growth factor I and hypoxia inducible factor 1α in vascular endothelial growth factor expression in type 2 diabetes. in Annals of clinical and laboratory science 2013
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Rat (Rattus) HIF1A ELISA Kit for Sandwich ELISA - ABIN368077
Rodríguez-Gómez, Banegas, Wangensteen, Quesada, Jiménez, Gómez-Morales, OValle, Duarte, Vargas: Influence of thyroid state on cardiac and renal capillary density and glomerular morphology in rats. in The Journal of endocrinology 2013
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Human HIF1A ELISA Kit for Sandwich ELISA - ABIN1115458
Chandravanshi, Bhonde: Small molecules exert anti-apoptotic effect and reduce oxidative stress augmenting insulin secretion in stem cells engineered islets against hypoxia. in European journal of pharmacology 2016
Human HIF1A ELISA Kit for Sandwich ELISA - ABIN2344926
Ohyama, Toyomura, Tachibana, Isonishi, Takahashi, Ishikawa: Establishment and characterization of a clear cell carcinoma cell line, designated NOCC, derived from human ovary. in Human cell 2016
Human HIF1A ELISA Kit for Sandwich ELISA - ABIN1081535
Sun, Wang, Liu, Lin, Hua: Resveratrol abrogates the effects of hypoxia on cell proliferation, invasion and EMT in osteosarcoma cells through downregulation of the HIF-1? protein. in Molecular medicine reports 2014
Pig (Porcine) HIF1A ELISA Kit for Sandwich ELISA - ABIN368480
Gyöngyösi, Hemetsberger, Posa, Charwat, Pavo, Petnehazy, Petrasi, Pavo, Hemetsberger, Benedek, Benedek, Benedek, Kovacs, Kaun, Maurer: Hypoxia-inducible factor 1-alpha release after intracoronary versus intramyocardial stem cell therapy in myocardial infarction. in Journal of cardiovascular translational research 2010
Activation of HIF-1 signaling pathway participates in the Ang II (show AGT ELISA Kits)-induced abdominal aortic aneurysm formation in mice
Depletion of KDM3A (show KDM3A ELISA Kits) coincided with the loss of SIAH1 (show SIAH1 ELISA Kits) induction and the accumulation of dimethylated H3K9 surrounding the SIAH1 (show SIAH1 ELISA Kits) promoter. Interestingly, KDM3A (show KDM3A ELISA Kits) expression was also up-regulated by nutritional stress in a HIF-1alpha dependent manner.
the proangiogenic capacity of implanted periosteal cells is HIF-1alpha regulated and that metabolic adaptations mediate post-implantation cell survival.
Oxidative stress increases in mouse arteriovenous shunts during early maturation, with increased expression of HIF-1alpha and its target genes NOX-2 (show CYBB ELISA Kits), HO-1 (show HMOX1 ELISA Kits), and VEGF-A (show VEGFA ELISA Kits).
HIF1a transcriptional activity is stimulated by Protein kinase A-dependent phosphorylation
Data indicate that the HIF-1alpha/VEGF-A (show VEGFA ELISA Kits) axis is an essential aspect of tumor immunity.
PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.
findings suggest that hypoxia, through HIF1A, contributes to the development and progression of pulmonary fibrosis through its regulation of ADORA2B (show ADORA2B ELISA Kits) expression on alternatively activated macrophages, cell differentiation, and production of profibrotic mediators
Death receptor5 pathway and mitochondrial pathway, which are likely mediated by HIF-1alpha, contribute to hypoxia-induced spermatocyte apoptosis.
Mechanical low shear stress activates HIF1alpha at atheroprone regions of arteries via nuclear factor-kappaB and Cezanne. HIF1alpha promotes atherosclerosis initiation at these sites by inducing excessive endothelial cell proliferation and inflammation via the induction of glycolysis enzymes.
Data show that NF-kappaB (show NFKB1 ELISA Kits)/p65 (show GORASP1 ELISA Kits) is required for the binding of zinc finger protein 91 (ZFP91 (show ZFP91 ELISA Kits)) to the HIF-1alpha promoter and for the transcriptional activation of HIF-1alpha gene mediated by ZFP91 (show ZFP91 ELISA Kits).
Nucleus pulposus cells regulate autophagy in a noncanonical fashion independent of MTOR (show FRAP1 ELISA Kits) and HIF1A signaling
LncRNA CPS1 (show CPS1 ELISA Kits)-IT1 acts as a tumor suppressor in hepatocellular carcinoma by reducing HIF-1alpha activation and suppressing epithelial-mesenchymal transition.
The results suggest that SESN2 (show SESN2 ELISA Kits) increases degradation of HIF-1A via AMPK (show PRKAA1 ELISA Kits)-PHD (show PDC ELISA Kits) regulation that contributes to inhibition of in vitro and in vivo tumorigenesis.
data implied that in vitro H1N1 infection induced nuclear translocation of HIF-1alpha without altering the expression of HIF-1alpha, which may promote the secretion of proinflammatory cytokines during H1N1 infection.
HIF1A and EPAS1 (show EPAS1 ELISA Kits) potentiate hypoxia-induced upregulation of INHA (show INHA ELISA Kits) expression in human term cytotrophoblasts in vitro.
MnTE-2-PyP (show PPA1 ELISA Kits) decreased p300 (show EP300 ELISA Kits) complex binding to a specific HRE motif within the PAI-1 (show SERPINE1 ELISA Kits) gene promoter region, suppressed H3K9 acetylation, and consequently, repressed PAI-1 (show SERPINE1 ELISA Kits) expression. Mechanistically, less p300 (show EP300 ELISA Kits) transcriptional complex binding is not due to the reduction of binding between p300 (show EP300 ELISA Kits) and HIF-1/CREB (show CREB1 ELISA Kits) transcription factors, but through inhibiting the binding of HIF-1/CREB (show CREB1 ELISA Kits) transcription factors to DNA
Despite the large concordance between P and matched M for the evaluated molecular alterations, potential actionable targets such as ESR1 (show ESR1 ELISA Kits) mutations were found only in M. This supports the importance of characterizing the M disease. Other targets we identified, such as HIF1A and IDO1 (show IDO1 ELISA Kits), warrant further investigation in this patient population.
High HIF1A expression is associated with pancreatic ductal adenocarcinoma.
a high expression of hypoxia induced factor-1a (HIF-1a) and heat shock protein 70 (HSP70 (show HSP70 ELISA Kits)) was noted
Induction of ischemic osteonecrosis results in IL-6 (show IL6 ELISA Kits) production in the articular cartilage through an HIF-1-dependent pathway.
Upregulation of VEGF (show VEGFA ELISA Kits) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.
HIF-1alpha activates Sox9 (show SOX9 ELISA Kits) expression and enhances Sox9 (show SOX9 ELISA Kits)-mediated transcriptional activity.
Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.
immunostaining for HIF-1alpha and HIF-2alpha (show EPAS1 ELISA Kits) was observed during endochondral ossification, whereas only HIF-2alpha (show EPAS1 ELISA Kits) was present at sites of intramembranous ossification
Downregulation of miR (show MYLIP ELISA Kits)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (show SIRT1 ELISA Kits) and recapitulates hypoxia preconditioning in cardiac myocytes.
Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.
inverse expression and localization pattern of HIF1A and vasohibins during different stages of ovarian function in cow
Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.
hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity
VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself
Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.
Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
HIF-1alpha-induced HSP70 (show HSP70 ELISA Kits) overexpression increased the expression levels of ECM (show MMRN1 ELISA Kits) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (show HSP70 ELISA Kits) expression
Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.
Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.
HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.
Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1
Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.
rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.
Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion
Our results suggest that these detoxification pathways are mediated by the hypoxia inducible factor HIF-1. Finally, we show that sulfide resistance varies among wild C. elegans and other nematode species, suggesting that tolerance to sulfide was naturally selected in certain habitats.
blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function.
HIF-1-mediated activation of 5-HT (show DDC ELISA Kits) signalling promotes axon regeneration by activating both the RhoA (show RHOA ELISA Kits) and cAMP pathways.
this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (show FMO2 ELISA Kits)).
AMPK (show PRKAA1 ELISA Kits) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (show ROS1 ELISA Kits)
Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.
Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (show PRKAA1 ELISA Kits) compromised C. elegans dauer larvae.
These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.
Data indicate that genes sqrd-1, ethe-1, cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide and hydrogen cyanide.
Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
, HIF1 alpha
, Hypoxia-inducible factor 1 alpha
, hypoxia-inducible factor 1-alpha
, ARNT-interacting protein
, ARNT interacting protein
, PAS domain-containing protein 8
, basic-helix-loop-helix-PAS protein MOP1
, class E basic helix-loop-helix protein 78
, hypoxia-inducible factor 1 alpha isoform I.3
, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
, hypoxia-inducible factor1alpha
, member of PAS protein 1
, member of PAS superfamily 1
, hypoxia-inducible factor 1 alpha
, hypoxia inducible factor 1 alpha subunit
, hypoxia inducible factor 1, alpha subunit