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examination of the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 in healthy subjects and patients with heart failure
Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3
In summary, cardiac expression of CRFR1, CRF, and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF/Ucn system in these patients.
circulating levels elevated and positively correlated with C-reactive protein in polycystic ovary syndrome
results show that activation of CRH receptors by CRH ligands stimulates VEGF-A expression in intestinal epithelial cells through the cAMP/CREB pathway
The paracrine actions of Ucn3 activate a negative feedback loop that promotes somatostatin release to ensure the timely reduction of insulin secretion upon normalization of plasma glucose.
The molecular modifications of urocortin 3[36-38] led to an improved understanding of the relationship between molecular structure and biological activity of this peptide, could be further tested for possible clinical treatment of depression
Data suggest that UCN3 expression can serve as a late stage maturation/differentiation marker in beta-cells during pancreogenesis. [REVIEW]
SCP inhibits a subpopulation of PVN neurons, especially OTergic magnocellular neurons, by enhancing the activity of GIRK channels via CRF-R2
study showed that Ucn2 and Ucn3 differentially regulate the LPS-induced TNF-alpha and IL-10 expression and secretion in trophoblast explants acting through CRH-R2. Ucn3 has an anti-inflammatory effect.
These data suggest a possible involvement of urocortin 2 and Ucn 3 in the mechanisms of endometriosis.
Confirm the anti-inflammatory function of VIP, through the modulation of the expression of CRF system that impacts in a reduction of mediators with inflammatory/destructive functions.
Placental Ucn2 and Ucn3 expression is sensitive to O(2) tensions and mediated by HIF-1alpha. In preeclampsia, the increased expression of both peptides may reflect a response to the oxidative stress.
SCP and UCN are potent activators of the p42/44 MAPK pathway, with SRP able to induce phosphorylation of p42/44 MAPK as well, albeit not as pronounced
CRH-R1:CRH-R2 ratio varied according to fat-depot type; whereas CRH-R1 expression was higher in sc fat than in visceral fat, the opposite was true for CRH-R2.
Expression of Ucn III/SCP in the human heart and kidney as well as brain and pituitary tissues and its presence in plasma and urine. Ucn III/SCP may therefore regulate the cardiac and renal function as a local factor and a circulating hormone.
Ucn 3 plays some physiological or pathological roles in the modulation of gastrointestinal functions during stressful conditions.
Ucn3 is produced in the normal adrenal gland and in adrenal tumors (both adrenocortical tumors and pheochromocytomas) and acts as an autocrine or paracrine regulator in both the normal and cancerous adrenal gland tissue.
UCN2 and UCN3 are expressed in human placenta, decidua, and fetal membranes and may be proposed as regulators of placental vascular endothelial tone.
Both peptides were immunolocalized in epithelial, stromal, and endothelial cells.
findings collectively suggest that the MeA Ucn3-CRF-R2 system modulates the ability of mice to cope with social challenges
Ucn3 KO mice displayed significantly increased ethanol intake and preference compared with WT. There were no long-term effects of chronic pain on alcohol drinking behavior, regardless of genotype.
This study aims to investigate the cellular localization of CRF and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
UCN3 expression enhances glucose disposal and signalling in muscle by an autocrine/paracrine mechanism that is separate from its pro-hypertrophic effects.
Leptin regulates corticotropin-releasing factor and urocortin 2/3 mRNA in hypothalamic neurons.
Urocortin 3 acting on CRFR2 in skeletal muscle of Ucn3(+) mice results in a metabolic phenotype, with lean body composition and protection against diet-induced obesity and hyperglycaemia.
In this study, the intracerebroventricularly administered Ucn3 exerted an inhibitory effect on food intake, although the potency for decreasing food intake differed with the experimental conditions.
The results of this study suggested a novel role for UCN3 and CRH-R2 related to the processing of social cues and to the establishment of social memories.
demonstrate the involvement of the hypothalamic neuropeptide Urocortin-3 in modulating septal and hypothalamic nuclei responsible for anxiety-like behaviors and metabolic functions, respectively.
pancreatic Ucn III acting through CRFR2 is involved in the local regulation of glucagon and insulin secretion.
CRFR2beta selective Ucn-II or Ucn-III will protect cardiomyocytes and the ex vivo Langendorff perfused rat heart from ischemia reperfusion injury by activation of ERK1/2-p42, 44.
Mouse Urocortin III is expressed in brain regions involved in stress-related behaviours, and its expression in the hypothalamus increases following restraint. Administration of mUcnIII stimulates reduced anxiety.
endogenous Ucn 3 in the pancreas is induced under excessive caloric conditions and acts locally to augment insulin production
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.
, ucn III
, urocortin III
, Urocortin II
, Urocortin III
, urocortin 3
, urocortin 3 (stresscopin)