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PPP1CA Products

(Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured PPP1CA Categories

PPP1CA Antibodies

High quality antibodies with extensive validation data.

PPP1CA ELISA Kits

Reliable ELISA kits for a wide range of species.

PPP1CA Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PPP1CA Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application ICC, IF, IHC (p), WB
Validations
  • (1)
  • (5)
Cat. No. ABIN2856071
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (3)
Cat. No. ABIN7169304
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, WB
Validations
  • (3)
Cat. No. ABIN7269674
Quantity 100 μL
Datasheet Datasheet

Recommended PPP1CA ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969734
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6206787
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6206788
Quantity 96 tests
Datasheet Datasheet

Recommended PPP1CA Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094721
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134581
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315939
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our PPP1CA products

Wu, Zhang, Peirats-Llobet, Belda-Palazon, Wang, Cui, Yu, Rodriguez, An: "Ubiquitin Ligases RGLG1 and RGLG5 Regulate Abscisic Acid Signaling by Controlling the Turnover of Phosphatase PP2CA." in: The Plant cell, Vol. 28, Issue 9, pp. 2178-2196, (2016) (PubMed).

Wei, Ngo, Wu, Lee: "Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint." in: Molecular biology of the cell, Vol. 22, Issue 19, pp. 3584-94, (2012) (PubMed).

Chen, Kesler, Paschal, Balk: "Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1." in: The Journal of biological chemistry, Vol. 284, Issue 38, pp. 25576-84, (2009) (PubMed).

Perry, Yang, Soora, Salma, Marback, Naghibi, Ilyas, Chan, Gordon, McDermott: "Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1alpha represses MEF2-dependent gene expression." in: Molecular and cellular biology, Vol. 29, Issue 12, pp. 3355-66, (2009) (PubMed).

Gao, Zhou, Xie, Zhang, Rahmeh, Huang, Lee, Lee: "Protein phosphatase-1 is targeted to DNA polymerase delta via an interaction with the p68 subunit." in: Biochemistry, Vol. 47, Issue 43, pp. 11367-76, (2008) (PubMed).

Moorhead, Trinkle-Mulcahy, Nimick, De Wever, Campbell, Gourlay, Lam, Lamond: "Displacement affinity chromatography of protein phosphatase one (PP1) complexes." in: BMC biochemistry, Vol. 9, pp. 28, (2008) (PubMed).

Luo, Peterson, Garcia, Coombs, Kofahl, Heinrich, Shabanowitz, Hunt, Yost, Virshup: "Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex." in: The EMBO journal, Vol. 26, Issue 6, pp. 1511-21, (2007) (PubMed).

Eto, Kirkbride, Elliott, Lo, Brautigan: "Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions." in: The Journal of biological chemistry, Vol. 282, Issue 24, pp. 17806-15, (2007) (PubMed).

Hsu, Huang, Seasholtz, Potter, Gollin: "Gene amplification and overexpression of protein phosphatase 1alpha in oral squamous cell carcinoma cell lines." in: Oncogene, Vol. 25, Issue 40, pp. 5517-26, (2006) (PubMed).

Zhou, Boomer, Tan: "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1." in: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49551-61, (2004) (PubMed).

Synonyms and alternative names related to PPP1CA

protein phosphatase 1 catalytic subunit alpha (PPP1CA), protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca), protein phosphatase 1 catalytic subunit alpha (Ppp1ca), protein phosphatase 1, catalytic subunit, alpha isozyme L homeolog (ppp1ca.L), protein phosphatase 1, catalytic subunit, alpha isozyme (ppp1ca), protein phosphatase 1, catalytic subunit, alpha isozyme a (ppp1caa), dism2, PP-1A, PP1A, PP1alpha, PPP1A, ppp1a, Ppp1c, wu:fc04c08, wu:fc09b07, wu:fc30g11, wu:fe05h08, zgc:85729

Protein level used designations for PPP1CA

  • protein phosphatase 1, catalytic subunit, alpha isoform
  • serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit
  • serine/threonine-protein phosphatase PP1-alpha catalytic subunit
  • PP-1A
  • Protein phosphatase type 1 alpha, catalytic subunit
  • protein phosphatase-1d
  • ppp1ca
  • protein phosphatase 1, catalytic subunit, alpha
  • PP1 alpha
  • protein phosphatase 1 alpha
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