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Data show that TopBP1 and Nbs1 associate with the N-terminal region of Mdc1 in egg extracts.
MRN (Mre11 (show MRE11A Proteins), Rad50 (show RAD50 Proteins), and Nbs1) complex, CtIP (show RBBP8 Proteins), and BRCA1 are required for both the removal of Top2 (show TOP2 Proteins)-DNA adducts and the subsequent resection of Top2 (show TOP2 Proteins)-adducted DSB ends.
MRN (MRE11 (show MRE11A Proteins)-RAD50 (show RAD50 Proteins)-NBS1) complex has role in ATR activation via TOPBP1 (show TOPBP1 Proteins) recruitment.
Dna2 co-localizes in foci with RPA (show RPA1 Proteins) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Proteins). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 and ATM (show ATM Proteins).
Results indicate a role for the X. laevis Mre11 (show MRE11A Proteins)/Rad50 (show RAD50 Proteins)/Nbs1 complex in microhomology-mediated end joining.
Through nuclear magnetic resonance three-dimensional structure determination, data demonstrate that there is a second BRCT domain (BRCT2) in Nbs1.
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM (show ATM Proteins) promotes the TopBP1 (show TOPBP1 Proteins)-dependent activation of ATR-ATRIP (show ATRIP Proteins) in response to double-stranded DNA breaks.
suggests that Mre11 (show MRE11A Proteins)-Rad50 (show RAD50 Proteins)-Nbs1 inactivation participates in the down-regulation of damage signaling during checkpoint recovery following double-strand breaks repair.
During transition from the pluripotent stage towards the neural developmental stage, NLRP2 is differentially expressed in bipolar patient derived cells compared to control derived cells.
No disease-causing mutations were identified in NLRP2, NLRP7 and KHDC3L in cohorts of unexplained infertility and recurrent pregnancy loss.
This study indicates that polymorphisms in SPARC and NLRP2 are related to rheumatoid arthritis susceptibility in a Chinese Han population.
Findings suggest that NLR family pyrin domain containing 2 (NLRP2P) is a processed pseudogene that regulates NF-kappaB (show NFKB1 Proteins) RelA/p65 (show NFkBP65 Proteins) activity and thus represents the newest member of the POP (show PREP Proteins) family, pyrin (show MEFV Proteins)-only protein 4 (POP4 (show POP4 Proteins); NLRP4).
The results of this study suggest that the astrocytic NLRP2 inflammasome is an important component of the CNS inflammatory response
There is a significant association of a tag single-nucleotide polymorphism (SNP) of NLRP7 (rs26949) with idiopathic recurrent miscarriage
single nucleotide polymorphisms in NALP2 gene is associated with arsenic induced skin lesions, peripheral neuropathy, eye problem and respiratory diseases.
Observations suggest that although NLRP7 and C6orf221 mutations are related to diploid biparental FRHMs, neither of these genes, nor NLRP2, are related to diploid HMs (show CTSC Proteins) with biparental contributions to the molar genome.
POP2 (show CNOT8 Proteins) acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix
Our observations are the first to implicate SPARC (show SPARC Proteins), SLPI (show SLPI Proteins), and NLRP2, a component of the innate immune system, in the pathogenesis of axial spondyloarthropathy
This work identifies Nlrp2 as a critical regulator of oocyte quality
high expression of NLRP2, especially in astrocytes, may play important roles in the pathophysiological process of ischemic stroke and has potential clinical value for the treatment of ischemic stroke.
Nlrp2 is a member of the mammalian maternal effect genes and required for early embryonic development in the mouse.
POP2 (show CNOT7 Proteins) acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1\; MIM 147678) by Toll-like receptors (see TLR4\; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003
NLR family, pyrin domain containing 2
, NACHT, leucine rich repeat and PYD containing 2
, NACHT, LRR and PYD domains-containing protein 2-like
, Nijmegen breakage syndrome 1
, nijmegen breakage syndrome protein 1 homolog
, NACHT, LRR and PYD containing protein 2
, NACHT, LRR and PYD domains-containing protein 2
, PYRIN domain and NACHT domain-containing protein 1
, PYRIN-containing APAF1-like protein 2
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2
, nucleotide-binding site protein 1