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IPO11 provides protection in another way, the researchers found. The transport receptor also shuttles UBE2E1, an enzyme necessary for PTEN ubiquitination, into the nucleus. Thanks to IPO11, normal cells keep all of their UBE2E1 in the nucleus, allowing PTEN to continue functioning in the cytoplasm. In cells lacking IPO11, UBE2E1 remains in the cytoplasm and promotes the destruction of PTEN.
IPO11-HTR1A (show HTR1A Proteins) is a significant risk gene region for attention deficit hyperactivity disorder in Caucasians.
Data indicate that ubiquitin-conjugating enzyme (show Ube2t Proteins) UBE2E3 (show UBE2E3 Proteins) and importin 11 (Imp (show IMPA1 Proteins)-11)promote the nuclear accumulation and activity of transcription factor NF-E2 (show NFE2 Proteins) (Nrf2 (show GABPA Proteins)) by restricting the transcription factor from partitioning to the mitochondria
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1\; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000
, Ran binding protein 11
, ran-binding protein 11