COL4a2 Protein (AA 1493-1712, partial) (His tag)
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- Target See all COL4a2 (COL4A2) Proteins
- COL4a2 (COL4A2) (Collagen, Type IV, alpha 2 (COL4A2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1493-1712, partial
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This COL4a2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS), ELISA
- Sequence
- VKHSQTDQEP MCPVGMNKLW SGYSLLYFEG QEKAHNQDLG LAGSCLARFS TMPFLYCNPG DVCYYASRND KSYWLSTTAP LPMMPVAEDE IKPYISRCSV CEAPAIAIAV HSQDVSIPHC PAGWRSLWIG YSFLMHTAAG DEGGGQSLVS PGSCLEDFRA TPFIECNGGR GTCHYYANKY SFWLTTIPEQ SFQGSPSADT LKAGLIRTHI SRCQVCMKNL
- Characteristics
- Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Ref.13 Ref.17 Ref.18 Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. Ref.13 Ref.17 Ref.18
- Purity
- 90 %
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Collagen, Type IV, alpha 2 (COL4A2) (AA 1486-1712) protein (His tag)
Crystallography grade COL4A2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Collagen, Type IV, alpha 2 (COL4A2) (AA 1481-1707) protein (His tag)Crystallography grade COL4A2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Collagen, Type IV, alpha 2 (COL4A2) (AA 184-1712) protein (His tag)Crystallography grade COL4A2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Collagen, Type IV, alpha 2 (COL4A2) (AA 184-1707) protein (His tag)Crystallography grade COL4A2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
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- Comment
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Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 6M guanidine hydrochloride, 20mM Tris
- Storage
- -20 °C
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- Target
- COL4a2 (COL4A2) (Collagen, Type IV, alpha 2 (COL4A2))
- Alternative Name
- Collagen alpha-2(IV) chain (COL4A2 Products)
- Synonyms
- col4a2-a Protein, zCanstatin Protein, ICH Protein, POREN2 Protein, Col4a-2 Protein, collagen, type IV, alpha 2 L homeolog Protein, collagen type IV alpha 2 chain Protein, collagen, type IV, alpha 2 Protein, col4a2.L Protein, COL4A2 Protein, col4a2 Protein, Col4a2 Protein
- Molecular Weight
- 28.3 kD
- UniProt
- P08572
