CARD18 Protein (His tag)

Catalog No. ABIN1098230

Product Details

Target: CARD18 (Caspase Recruitment Domain-Containing Protein 18 (ICEBERG) (CARD18))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CARD18 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Purification: purified by chromatography

Purity: > 95 % by SDS - PAGE

Application Details

Comment:

Synonyms: Caspase recruitment domain-containing protein 18, ICEBERG, pseudo-ICE, UNQ5804

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 1 MM DTT,10% glycerol, 0.1 M NaCl

Storage: 4 °C

Storage Comment: Avoid repeated freezing and thawing cycles.

Target Details

Target: CARD18 (Caspase Recruitment Domain-Containing Protein 18 (ICEBERG) (CARD18))

Alternative Name: CARD18 (CARD18 Products)

Synonyms: ICEBERG Protein, UNQ5804 Protein, pseudo-ICE Protein, caspase recruitment domain family member 18 Protein, CARD18 Protein

Background: Caspase recruitment domain-containing protein 18, also known as CARD18, is a member of the death-domain-fold superfamily that is induced by proinflammatory stimuli. It consists essentially only of a CARD, inhibits generation of IL-1b by interacting with caspase-1 and preventing association with RIP 2. The association of CARD18 with caspase-1 is facilitated by the charge-charge interactions between the prodomain of caspase-1 and the surface charge of CARD18. Recombinant human CARD18 proetin, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molecular Weight: 12.3 kDa (110aa), confirmed by MALDI-TOF

NCBI Accession: NP_067546