Annexin A5 (ANXA5) protein (GST tag)

Details for Product No. ABIN1344454
Protein Name
  • anx
  • anx5
  • ANX V
  • anxa5
  • cb989
  • wu:fa98f06
  • wu:fj10f10
  • MGC89158
  • ANX5
  • ENX2
  • PP4
  • RPRGL3
  • Anx5
  • R74653
  • LC5
  • enx2
  • annexin A5
  • annexin A5b
  • Annexin A5
  • annexin A5 L homeolog
  • ANXA5
  • anxa5b
  • anxa5
  • Anxa5
  • anxa5.L
Origin
Human
37
4
3
3
3
3
1
1
1
Source
Escherichia coli (E. coli)
43
8
1
1
1
Protein Type
Recombinant
Purification tag / Conjugate
This Annexin V protein is labelled with GST tag.
Application
SDS-PAGE (SDS)
Options
Specificity Binds to phosphatidylserine (PS).
Cross-Reactivity Human
Characteristics Recombinant human annexin V fused to a GST-tag.
Purity >95 % (SDS-PAGE)
Protein Name
Background Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e.g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.
Molecular Weight ~52kDa (SDS-PAGE)
UniProt P08758
Pathways Apoptosis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 100 μL sterile water.
Concentration 1 mg/mL
Buffer Lyophilized. In PBS, pH 7.4.
Storage 4 °C,-20 °C
Storage Comment Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Reconstituted solutions can be kept at 4°C under sterile conditions for one week or should be frozen in aliquots at -20°C.
Expiry Date 12 months
Product cited in: Morizono, Chen: "Role of phosphatidylserine receptors in enveloped virus infection." in: Journal of virology, Vol. 88, Issue 8, pp. 4275-90, 2014 (PubMed).