Mannosidase, Alpha, Class 1B, Member 1 (MAN1B1) (AA 106-699) protein (His tag)

Details for Product No. ABIN1691335
Protein Name
  • erman1
  • mana-er
  • MAN1B1
  • ERMAN1
  • MANA-ER
  • MRT15
  • E430019H13Rik
  • ERMan1
  • Gm108
  • RGD1563595
  • mannosidase alpha class 1B member 1
  • mannosidase, alpha, class 1B, member 1 L homeolog
  • endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
  • mannosidase, alpha, class 1B, member 1
  • MAN1B1
  • man1b1.L
  • LOC480667
  • man1b1
  • Man1b1
Protein Characteristics
AA 106-699
3
1
1
1
1
1
Origin
Human
6
2
1
Source
Human Cells
2
2
2
1
1
1
Protein Type
Recombinant
Purification tag / Conjugate
This MAN1B1 protein is labelled with His tag.
Application
Functional Studies (Func)
Options
Purpose Recombinant Human ER α-1,2-Mannosidase/MAN1B1 (C-6His)
Sequence DHWKALAFRL EEEQKMRPEI AGLKPANPPV LPAPQKADTD PENLPEISSQ KTQRHIQRGP PHLQIRPPSQ DLKDGTQEEA TKRQEAPVDP RPEGDPQRTV ISWRGAVIEP EQGTELPSRR AEVPTKPPLP PARTQGTPVH LNYRQKGVID VFLHAWKGYR KFAWGHDELK PVSRSFSEWF GLGLTLIDAL DTMWILGLRK EFEEARKWVS KKLHFEKDVD VNLFESTIRI LGGLLSAYHL SGDSLFLRKA EDFGNRLMPA FRTPSKIPYS DVNIGTGVAH PPRWTSDSTV AEVTSIQLEF RELSRLTGDK KFQEAVEKVT QHIHGLSGKK DGLVPMFINT HSGLFTHLGV FTLGARADSY YEYLLKQWIQ GGKQETQLLE DYVEAIEGVR THLLRHSEPS KLTFVGELAH GRFSAKMDHL VCFLPGTLAL GVYHGLPASH MELAQELMET CYQMNRQMET GLSPEIVHFN LYPQPGRRDV EVKPADRHNL LRPETVESLF YLYRVTGDRK YQDWGWEILQ SFSRFTRVPS GGYSSINNVQ DPQKPEPRDK MESFFLGETL KYLFLLFSDD PNLLSLDAYV FNTEAHPLPI WTPAVDHHHH HH
Characteristics Recombinant Human Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-alpha-Mannosidase/MAN1B1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Asp106-Ala699) of Human MAN1B1 fused with a polyhistidine tag at the C-terminus.
Purity > 95 % as determined by reducing SDS-PAGE.
Sterility 0.2 μm filtered
Endotoxin Level Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
Protein Name
Sub Type Fusionprotein
Background Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-alpha-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
Alternative Names: Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase, ER Alpha-1,2-Mannosidase, ER Mannosidase 1, ERMan1, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, Mannosidase Alpha Class 1B Member 1, MAN1B1
Molecular Weight 68.7 kDa
UniProt Q9UKM7
Restrictions For Research Use only
Format Liquid
Reconstitution It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Buffer Supplied as a 0.2 μm filtered solution of 50 mM TrisHCL,10 mM reduced Glutathione, pH 8.0.
Handling Advice Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
Storage -80 °C
Storage Comment Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
Expiry Date 6 months
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