ITIH3 Protein (AA 35-651) (His tag)

Catalog No. ABIN1945423

Product Details

Target: ITIH3 (Inter alpha Globulin Inhibitor H3 (ITIH3))

Protein Type: Recombinant

Protein Characteristics: AA 35-651

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This ITIH3 protein is labelled with His tag.

Purpose: Recombinant Human Inter-α-Trypsin Inhibitor Heavy Chain H3/ITIH3 (C-6His)

Sequence: LPEGVANGIE VYSTKINSKV TSRFAHNVVT MRAVNRADTA KEVSFDVELP KTAFITNFTL TIDGVTYPGN VKEKEVAKKQ YEKAVSQGKT AGLVKASGRK LEKFTVSVNV AAGSKVTFEL TYEELLKRHK GKYEMYLKVQ PKQLVKHFEI EVDIFEPQGI SMLDAEASFI TNDLLGSALT KSFSGKKGHV SFKPSLDQQR SCPTCTDSLL NGDFTITYDV NRESPGNVQI VNGYFVHFFA PQGLPVVPKN VAFVIDISGS MAGRKLEQTK EALLRILEDM QEEDYLNFIL FSGDVSTWKE HLVQATPENL QEARTFVKSM EDKGMTNIND GLLRGISMLN KAREEHRIPE RSTSIVIMLT DGDANVGESR PEKIQENVRN AIGGKFPLYN LGFGNNLNYN FLENMALENH GFARRIYEDS DADLQLQGFY EEVANPLLTG VEMEYPENAI LDLTQNTYQH FYDGSEIVVA GRLVDEDMNS FKADVKGHGA TNDLTFTEEV DMKEMEKALQ ERDYIFGNYI ERLWAYLTIE QLLEKRKNAH GEEKENLTAR ALDLSLKYHF VTPLTSMVVT KPEDNEDERA IADKPGEDAE ATPVSPAMSY LTSYQPPQNP YYYVDGDVDH HHHHH

Characteristics: Recombinant Human Inter-alpha-trypsin inhibitor heavy chain H3/ITIH3 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (AA 35-651) of Human ITIH3 fused with a polyhistidine tag at the C-termin

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ITIH3 (Inter alpha Globulin Inhibitor H3 (ITIH3))

Alternative Name: Inter-alpha-Trypsin Inhibitor Heavy Chain H3/ITIH3 (ITIH3 Products)

Synonyms: AW108094 Protein, Intin3 Protein, Itih-3 Protein, PAIHC3 Protein, H3P Protein, ITI-HC3 Protein, Itih3 Protein, inter-alpha trypsin inhibitor, heavy chain 3 Protein, inter-alpha-trypsin inhibitor heavy chain 3 Protein, Itih3 Protein, ITIH3 Protein

Background: ITIH3, which is short for Inter-alpha-trypsin inhibitor heavy chain H3, is a 890 aa. protein. It is secreted expression, and belongs to the ITIH family. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. ITTH3 may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

Molecular Weight: 70.4 kDa

UniProt: Q06033

Pathways: Glycosaminoglycan Metabolic Process