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CA2 Protein (Carbonic Anhydrase II) (AA 1-260) (His tag)

CA2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Pubmed (1 reference)
Catalog No. ABIN2180674
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  • Target See all CA2 Proteins
    CA2 (Carbonic Anhydrase II (CA2))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-260
    Origin
    • 12
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Source
    • 16
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This CA2 protein is labelled with His tag.
    Sequence
    AA 1-260
    Characteristics
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 30 kDa. The protein migrates as 30 kDa under reducing (R) condition (SDS-PAGE).
    Purity
    >95 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    20 mM Tris, 150 mM NaCl, pH 8.0
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Wang, Zhou: "Dual-Valve and Counter-Flow Surface Plasmon Resonance." in: Analytical chemistry, Vol. 90, Issue 8, pp. 4972-4977, (2019) (PubMed).

  • Target
    CA2 (Carbonic Anhydrase II (CA2))
    Alternative Name
    Carbonic Anhydrase II (CA2 Products)
    Synonyms
    CG6906, CT21171, Dmel\\CG6906, CA-2, caII, car2, ca ii, ca-ii, BETA CA2, BETA CARBONIC ANHYDRASE 2, CA18, CARBONIC ANHYDRASE 18, CARBONIC ANHYDRASE 2, T9L3.40, T9L3_40, carbonic anhydrase 2, LOC100135827, AI131712, CAII, Ca2, Car-2, Ltw-5, Lvtw-5, CA-II, CAC, Car2, CAR3, Carbonic anhydrase 2, carbonic anhydrase 2 L homeolog, carbonic anhydrase 2, carbonic anhydrase 1, carbonic anhydrase II, carbonic anhydrase, alpha type, periplasmic, CAH2, ca2.L, ca2, CA2, HCAG_04637, LOC100135827, LOC100635510, Car2, Ca2, LOC100154873, LOC101113341
    Background
    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. They are, therefore, classified as metalloenzymes. There are at least five distinct CA families (α, β, γ, δ and ε). These families have no significant amino acid sequence similarity and in most cases are thought to be an example of convergent evolution. The α-CAs are found in humans. Carbonic anhydrase II (CA2) is also known as Carbonate dehydratase II, Carbonic anhydrase C, is one of fourteen forms of human α carbonic anhydrases. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. Carbonic anhydrase II has been shown to interact with Band 3 and Sodium-hydrogen antiporter 1.
    Molecular Weight
    30.1 kDa
    NCBI Accession
    NP_000058
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