TNFRSF10A Protein (AA 24-239) (His tag)
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- Target See all TNFRSF10A Proteins
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 24-239
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TNFRSF10A protein is labelled with His tag.
- Sequence
- AA 24-239
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24 kDa. The protein migrates as 22-24 kDa under reducing (R) condition (SDS-PAGE).
- Purity
- >90 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product TNFRSF10A Protein
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Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) protein (His-Avi Tag,Biotin)
TNFRSF10A Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 34-239) protein (Fc Tag)TNFRSF10A Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) protein (His-Avi Tag)TNFRSF10A Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 103-239) protein (His-DYKDDDDK-Strep II Tag)TNFRSF10A Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 24-239) protein (Fc Tag)TNFRSF10A Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) protein (His tag)TNFRSF10A Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 379-445) protein (His-IF2DI Tag)TNFRSF10A Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 24-239) protein (His tag)TNFRSF10A Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 105-204) protein (GST tag)TNFRSF10A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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- Target
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
- Alternative Name
- TRAIL R1 (TNFRSF10A Products)
- Background
- Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.
- Molecular Weight
- 24.8 kDa
- NCBI Accession
- NP_003835
- Pathways
- Apoptosis, Positive Regulation of Endopeptidase Activity
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