BPTF Protein (AA 2791-2911) (His tag,DYKDDDDK Tag)
BPTF
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
Bind, ScA
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- Target See all BPTF products
- BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2791-2911
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This BPTF protein is labelled with His tag,DYKDDDDK Tag.
- Application
- Binding Studies (Bind), Screening Assay (ScA)
- Characteristics
- The peptide corresponding to amino acids 2791-2911 that contains the bromodomain sequences of BPTF / FALZ (accession number NP_872579.2) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 20.3 kDa.
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Bromodomain PHD Finger Transcription Factor (BPTF) (AA 2796-2907) protein (His tag)
BPTF Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
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- Application Notes
- Recombinant BPTF / FALZ (2791-2911) is suitable for use in binding assays, inhibitor screening, and selectivity profiling.
- Restrictions
- For Research Use only
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- Handling Advice
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- Storage
- -80 °C
- Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- Target
- BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))
- Alternative Name
- BPTF / FALZ (BPTF Products)
- Background
- Bromodomain PHD finger transcription factor (BPTF), also known as Fetal Alzheimer antigen (FALZ), is a histone-binding component of NuRF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. BPTF protein contains a DNA-binding domain, a zinc finger motif and a bromodomain. Bromodomains recognize acetylated histone lysine residues and function as 'readers' of these epigenetic histone marks to regulate chromatin structure and gene expression by linking associated proteins to the acetylated nucleosomal targets. BPTF also specifically recognizes H3 tails trimethylated on lysine 4 (H3K4me3), which mark transcription start sites of virtually all active genes. It may also regulate transcription through direct binding to DNA or transcription factors.
- Molecular Weight
- 20.3 kDa
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