CYP21A2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2712755

Product Details

Target: CYP21A2 (Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 (CYP21A2))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CYP21A2 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human CYP21A2 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: CYP21A2 (Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 (CYP21A2))

Alternative Name: Cyp21a2 (CYP21A2 Products)

Synonyms: CA21H Protein, CAH1 Protein, CPS1 Protein, CYP21 Protein, CYP21B Protein, P450c21B Protein, 21-OH Protein, 21OH Protein, 21OHA Protein, 21OHB Protein, CYP21OH-A Protein, Cyp21 Protein, Cyp21-ps1 Protein, Cyp21B Protein, Cyp21a2-ps Protein, Cyp21a2ps Protein, Oh21-1 Protein, Oh21-2 Protein, CYP21A Protein, 21-OHase Protein, cytochrome P450 family 21 subfamily A member 2 Protein, cytochrome P450, family 21, subfamily a, polypeptide 1 Protein, cytochrome P450c21 Protein, cytochrome P450, family 21, subfamily A, polypepide 2 Protein, cytochrome P450, family 21, subfamily A, polypeptide 2 Protein, steroid 21-hydroxylase-like Protein, CYP21A2 Protein, Cyp21a1 Protein, LOC101094596 Protein

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 55.8 kDa

NCBI Accession: NP_000491

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process