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Bardet-Biedl Syndrome 7 (BBS7) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag) Protein

BBS7 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD
Catalog No. ABIN2715168
$888.80
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20 μg
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  • Target
    BBS7
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 2
    Origin
    Human
    Source
    HEK-293 Cells
    • 2
    • 2
    Purification tag / Conjugate
    This BBS7 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
    Specificity
    Optimal preservation of protein structure, post-translational modifications and functions.
    Characteristics
    • Recombinant human BBS7 (transcript variant 2) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    > 50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    BBS7
    Synonyms
    BBS7, bbs2l1, BBS2L1, id:ibd5048, zgc:153772, 8430406N16Rik, Bardet-Biedl syndrome 7, bardet-biedl syndrome 7, Bardet-Biedl syndrome 7 L homeolog, Bardet-Biedl syndrome 7 (human), BBS7, bbs7, MICPUN_100192, MICPUCDRAFT_16331, bbs7.L, Bbs7
    Background
    This gene encodes one of eight proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Oct 2014].
    Molecular Weight
    75.3 kDa
    NCBI Accession
    NP_060660
    Pathways
    Hedgehog Signaling
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