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BIN1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

BIN1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2715269
$1,112.40
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20 μg
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  • Target See all BIN1 Proteins
    BIN1 (Bridging Integrator 1 (BIN1))
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 2
    Origin
    • 4
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This BIN1 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human BIN1 / AMPHL (transcript variant 2) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    BIN1 (Bridging Integrator 1 (BIN1))
    Alternative Name
    Bin1,amphl (BIN1 Products)
    Synonyms
    bin1 Protein, MGC53185 Protein, amph2 Protein, amphl Protein, sh3p9 Protein, MGC76187 Protein, cb57 Protein, zgc:86701 Protein, BIN1 Protein, AMPH2 Protein, AMPHL Protein, SH3P9 Protein, ALP-1 Protein, Amphl Protein, BRAMP-2 Protein, bridging integrator 1 Protein, bridging integrator 1 S homeolog Protein, bridging integrator 1b Protein, BIN1 Protein, bin1.S Protein, bin1 Protein, bin1b Protein, Bin1 Protein
    Background
    This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
    Molecular Weight
    59.8 kDa
    NCBI Accession
    NP_647594
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