POP1 Protein (AA 2-89) (GST tag)
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- Target See all POP1 Proteins
- POP1 (Processing of Precursor 1, Ribonuclease P/MRP Subunit (S. Cerevisiae) (POP1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-89
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This POP1 protein is labelled with GST tag.
- Application
- SDS-PAGE (SDS)
- Purpose
- POP1 (human) (rec.)
- Cross-Reactivity
- Human
- Characteristics
- Human POP1 (aa 2-89) is fused at the N-terminus to a GST tag.
- Purity
- >95 % (SDS-PAGE)
- Top Product
- Discover our top product POP1 Protein
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Processing of Precursor 1, Ribonuclease P/MRP Subunit (S. Cerevisiae) (POP1) (AA 1-1024) protein (His tag)
custom-made POP1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 100 μL sterile water.
- Concentration
- 0.1 mg/mL
- Buffer
- Contains PBS.
- Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- Expiry Date
- 6 months
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- Target
- POP1 (Processing of Precursor 1, Ribonuclease P/MRP Subunit (S. Cerevisiae) (POP1))
- Alternative Name
- POP1 (POP1 Products)
- Background
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Pyrin Domain-containing Protein 1, PAAD-only Protein 1, Pyrin-only Protein 1, PYC1
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins.
- Molecular Weight
- ~38 kDa
- UniProt
- Q8WXC3
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