Intercellular Adhesion Molecule 2 (ICAM2) (AA 25-223) protein (His tag)

Details for Product No. ABIN4370385
Protein Name
  • ICAM2
  • CD102
  • Icam-2
  • Ly-60
  • intercellular adhesion molecule 2
  • LOC506088
  • ICAM2
  • LOC616254
  • LOC100140873
  • Icam2
Protein Characteristics
AA 25-223
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Origin
Human
20
8
1
1
1
Source
Human Cells
9
8
7
4
2
1
Protein Type
Recombinant
Purification tag / Conjugate
This ICAM2 protein is labelled with His tag.
Application
Functional Studies (Func)
Options
Purpose Recombinant Human Intercellular Adhesion Molecule 2/ICAM-2/CD102 (C-6His)
Sequence KVFEVHVRPK KLAVEPKGSL EVNCSTTCNQ PEVGGLETSL DKILLDEQAQ WKHYLVSNIS HDTVLQCHFT CSGKQESMNS NVSVYQPPRQ VILTLQPTLV AVGKSFTIEC RVPTVEPLDS LTLFLFRGNE TLHYETFGKA APAPQEATAT FNSTADREDG HRNFSCLAVL DLMSRGGNIF HKHSAPKMLE IYEPVSDSQV DHHHHHH
Characteristics Recombinant Human Intercellular Adhesion Molecule 2/ICAM-2 produced by transfected human cells is a secreted protein with sequence (Lys25-Gln223) of Human ICAM2 fused with a polyhistidine tag at the C-terminus.
Purity > 95 % as determined by reducing SDS-PAGE.
Sterility 0.2 μm filtered
Endotoxin Level Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
Protein Name
Sub Type Fusionprotein
Background ICAM-2 is a 55-65 kD transmembrane glycoprotein possessing 2 extracellular Ig domains, a single transmembrane domain, and a short 26-amino acid cytoplasmic domain. ICAM-2 is expressed on most leukocytes, and is strongly expressed on vascular endothelial cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relation with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in diagnosis of trichinosis recent infections, and in monitoring the prognosis and response to treatment.
Alternative Names: Intercellular Adhesion Molecule 2, ICAM-2, CD102, ICAM2
Molecular Weight 23.13 kDa
UniProt P13598
Restrictions For Research Use only
Format Lyophilized
Reconstitution It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Buffer Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 2 mM CaCl2, 2 mM MgCl2, 5 % Threhalose, pH 7.2.
Handling Advice Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
Storage 4 °C/-20 °C/-80 °C
Storage Comment Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Expiry Date 3 months
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