THIO (AA 2-105) protein (GST tag)
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
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- Target
- THIO
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-105
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- GST tag
- Application
- SDS-PAGE (SDS)
- Sequence
- VKQIESKTAF QEALDAAGDK LVVVDFSATW CGPCKMIKPF FHSLSEKYSN VIFLEVDVDD CQDVASECEV KCMPTFQFFK KGQKVGEFSG ANKEKLEATI NELV
- Purification
- SDS-PAGE
- Purity
- > 90 %
-
THIO (AA 2-109) protein (His tag)
Origin: E. coli Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- THIO
- Background
- Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
- Molecular Weight
- 39 kDa
- UniProt
- P10599
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