Pituitary Homeobox 3 (PITX3) (AA 1-302), (full length) protein (His tag)

Details for Product No. ABIN5713730
Protein Name
Protein Characteristics
AA 1-302, full length
4
1
1
Origin
Mouse (Murine)
2
1
1
1
Source
Yeast
2
2
1
Protein Type
Recombinant
Purification tag / Conjugate
His tag
Application
SDS-PAGE (SDS)
Options
Sequence MEFGLLGEAE ARSPALSLSD AGTPHPPLPE HGCKGQEHSD SEKASASLPG GSPEDGSLKK KQRRQRTHFT SQQLQELEAT FQRNRYPDMS TREEIAVWTN LTEARVRVWF KNRRAKWRKR ERSQQAELCK GGFAAPLGGL VPPYEEVYPG YSYGNWPPKA LAPPLAAKTF PFAFNSVNVG PLASQPVFSP PSSIAASMVP SAAAAPGTVP GPGALQGLGG APPGLAPAAV SSGAVSCPYA SAAAAAAAAA SSPYVYRDPC NSSLASLRLK AKQHASFSYP AVPGPPPAAN LSPCQYAVER PV
Purification SDS-PAGE
Purity > 90 %
Protein Name
Background Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the tporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle.
Molecular Weight 33.7 kDa
UniProt O35160
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.1-2 mg/mL
Buffer 20 mM Tris-HCl based buffer, pH 8.0
Storage -80 °C,4 °C,-20 °C
Storage Comment Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Supplier Images
Image no. 1 for Pituitary Homeobox 3 (PITX3) (AA 1-302), (full length) protein (His tag) (ABIN5713730) Pituitary Homeobox 3 (PITX3) (AA 1-302), (full length) protein (His tag)