ICP47 (AA 1-88), (full length) protein (His tag)
Origin: Herpes Simplex Virus (HSV)
Host: Yeast
Recombinant
> 90 %
SDS
1 image
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- Target
- ICP47
- Protein Type
- Recombinant
- Protein Characteristics
- full length, AA 1-88
- Origin
- Herpes Simplex Virus (HSV)
- Source
- Yeast
- Purification tag / Conjugate
- His tag
- Application
- SDS-PAGE (SDS)
- Sequence
- MSWALEMADT FLDTMRVGPR TYADVRDEIN KRGREDREAA RTAVHDPERP LLRSPGLLPE IAPNASLGVA HRRTGGTVTD SPRNPVTR
- Purification
- SDS-PAGE
- Purity
- > 90 %
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
- Target
- ICP47
- Target Type
- Viral Protein
- Background
- Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. pty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
- Molecular Weight
- 11.79 kDa
- UniProt
- P03170
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