Integrin alpha 2b beta 3 (AA 32-993) (Active) protein (His tag)
Origin: Human
Host: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Active
-
- Target
- Integrin alpha 2b beta 3
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 32-993
- Origin
- Human
- Source
- HEK-293 Cells
- Purification tag / Conjugate
- His tag
- Sequence
- AA 32-993
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
-
- Target
- Integrin alpha 2b beta 3
- Background
- Integrin alpha IIb beta 3 exist in a conformational equilibrium clustered around four main states. These conformations range from a compact bent nodule to two partially extended intermediate conformers and finally to a fully upright state. Activation of blood platelets by physiological stimuli at sites of vascular injury induces inside-out signaling, resulting in a conformational change of the prototype Integrin alpha IIb beta 3 from an inactive to an active state competent to bind soluble fibrinogen. Furthermore, ligand occupancy of Integrin alpha IIb beta 3 outside-in signaling and additional conformational changes of the receptor, leading to the exposure of extracellular neoepitopes termed ligand-induced binding sites (LIBS), which are recognized by anti-LIBS monoclonal antibodies.
- Molecular Weight
- 111.4 kDa (ITGAIIb) & 81.8 kDa (ITGB3)
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