ITGAV/ITGB8 Protein (AA 31-988) (His tag)
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- Target See all ITGAV/ITGB8 products
- ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 31-988
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ITGAV/ITGB8 protein is labelled with His tag.
- Sequence
- AA 31-988
- Purity
- >95 % as determined by reduced SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-993) protein (His tag)
ITGAV/ITGB8 Origin: Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-992) (Active) protein (His tag)ITGAV/ITGB8 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-992) protein (His tag,AVI tag,Biotin)ITGAV/ITGB8 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))
- Alternative Name
- Integrin alpha V beta 8 (ITGAV/ITGB8 Products)
- Background
- Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.
- Molecular Weight
- 112.5 kDa (ITGAV) & 77.5 kDa (ITGB8)
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