P-Cadherin Protein (CDH3) (AA 18-654) (His tag)
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- Target See all P-Cadherin (CDH3) Proteins
- P-Cadherin (CDH3)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 18-654
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This P-Cadherin protein is labelled with His tag.
- Purpose
- Recombinant human CDH3 protein with C-terminal 6xHis tag
- Specificity
- CDH3 (Ser18-Gly654) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product CDH3 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- P-Cadherin (CDH3)
- Alternative Name
- CDH3 (CDH3 Products)
- Background
- This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]
- Molecular Weight
- predicted molecular mass of 60.9 kDa after removal of the signal peptide. The apparent molecular mass of CDH3-His is 70-100 kDa due to glycosylation.
- UniProt
- P22223
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