LOXL2 Protein (AA 26-774) (His tag)

Catalog No. ABIN7013009

Product Details

Target: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Protein Type: Recombinant

Protein Characteristics: AA 26-774

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This LOXL2 protein is labelled with His tag.

Purpose: Human LOXL2 Protein, His Tag (active enzyme)

Purity: >95 % as determined by reduced SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 20 mM MES, 50 mM NaCl, pH 6.5

Storage: -80 °C

Target Details

Target: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Alternative Name: LOXL2 (LOXL2 Products)

Background: Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Molecular Weight: 86.0 kDa

NCBI Accession: NP_002309

Pathways: Chromatin Binding