LGR5 Protein (AA 22-561) (His tag)
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- Target See all LGR5 Proteins
- LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 22-561
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This LGR5 protein is labelled with His tag.
- Characteristics
- Human LGR5 / GPR49 protein, His Tag
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product LGR5 Protein
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Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) (AA 22-543) protein (Fc Tag)
LGR5 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) proteinLGR5 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) (AA 22-561) protein (His tag)LGR5 Origin: Human Host: Yeast Recombinant > 90 % SDS
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
- Alternative Name
- LGR5 (LGR5 Products)
- Background
- LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.
- Molecular Weight
- 62.0 kDa
- NCBI Accession
- NP_003658
- Pathways
- WNT Signaling
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