ZNRF3 Protein (AA 56-219) (His tag)
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- Target See all ZNRF3 Proteins
- ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 56-219
- Origin
- Human
- Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ZNRF3 protein is labelled with His tag.
- Sequence
- AA 56-219
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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- Application Notes
- MALS verified
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))
- Alternative Name
- ZNRF3 (ZNRF3 Products)
- Synonyms
- BK747E2.3 Protein, RNF203 Protein, AA591877 Protein, BC019575 Protein, Gm1167 Protein, zinc and ring finger 3 Protein, Znrf3 Protein, ZNRF3 Protein
- Background
- The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.
- Molecular Weight
- 19.7 kDa
- NCBI Accession
- NP_001193927
- Pathways
- WNT Signaling
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