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TREM2 Protein (AA 19-174) (Fc Tag)

TREM2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Catalog No. ABIN7013683
$434.77
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  • Target See all TREM2 Proteins
    TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 19-174
    Origin
    • 12
    • 9
    • 2
    • 1
    Human
    Source
    • 11
    • 7
    • 3
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This TREM2 protein is labelled with Fc Tag.
    Sequence
    AA 19-174
    Characteristics
    Cynomolgus TREM2 Protein, His Tag
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
    Storage
    -20 °C
  • Target
    TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
    Alternative Name
    TREM2 (TREM2 Products)
    Synonyms
    TREM-A1 Protein, TREM-B1 Protein, TREM2 Protein, trem-2 Protein, trem2a Protein, trem2b Protein, trem2c Protein, TREM-2 Protein, Trem2a Protein, Trem2b Protein, Trem2c Protein, triggering receptor expressed on myeloid cells 2 Protein, trem-like transcript 2 protein Protein, TREM2 Protein, trem2 Protein, LOC100228399 Protein, Trem2 Protein
    Background
    Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of the immunoglobulin superfamily. The TREM2 is found in various tissue macrophages, such as CNS microglia, bone osteoclasts, alveolar, peritoneal and intestinal macrophages. TREM2 is also present on cultured bone marrow-derived macrophages and monocyte-derived dendritic cells. Some research have identified a rare variant of TREM2 that is a risk factor for Alzheimer disease (AD), which is the most common form of late-onset dementia.The extracellular region of TREM2 contains a single immunoglobulin superfamily domain and binds polyanionic ligands, such as bacterial lipopolysaccharide (LPS) and phospholipids8. Upon ligand binding, TREM2 transmits intracellular signals through an adaptor, DAP12 (also known as TYRO protein tyrosine kinase-binding protein (TYROBP)), which is associated with the transmembrane region of TREM2 and which recruits the protein tyrosine kinase SYK through its cytosolic immunoreceptor tyrosine-based activation motifs (ITAMs). TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.
    Molecular Weight
    43.9 kDa
    NCBI Accession
    NP_061838
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