CSRP1 Protein (His tag)
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- Target See all CSRP1 Proteins
- CSRP1 (Cysteine and Glycine-Rich Protein 1 (CSRP1))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CSRP1 protein is labelled with His tag.
- Purpose
- Recombinant Mouse CSRP1 Protein (His Tag)
- Sequence
- Met 1-Glu 193
- Characteristics
- A DNA sequence encoding the mouse CSRP1 (P97315) (Met 1-Glu 193) was expressed, with a polyhistide tag at the C-terminus.
- Purity
- > 95 % as determined by SDS-PAGE
- Top Product
- Discover our top product CSRP1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CSRP1 (Cysteine and Glycine-Rich Protein 1 (CSRP1))
- Alternative Name
- CSRP1 (CSRP1 Products)
- Background
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Background: Cysteine and glycine-rich protein 1, also known as Cysteine-rich protein 1, CSRP1 and CSRP, is a member of the CSRP family which may be involved in regulatory processes important for development and cellular differentiation. CSRP1 contains two LIM zinc-binding domains. The LIM / double zinc-finger motif found in CSRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Zebrafish CSRP1 is expressed in the mesendoderm and its derivatives. CSRP1 interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways. When CSRP1 message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. In addition, cardiac bifida is induced as a consequence of defects in cardiac mesoderm cell migration. CSRP1 acts as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs.
Synonym: AA408841;AA959891;AW545626;CRP1;Csrp
- Molecular Weight
- 22 kDa
- UniProt
- P97315
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