STXBP1 Protein (GST tag,His tag)
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- Target See all STXBP1 Proteins
- STXBP1 (Syntaxin Binding Protein 1 (STXBP1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This STXBP1 protein is labelled with GST tag,His tag.
- Purpose
- Recombinant Human STXBP1/UNC18A Protein (His & GST Tag)
- Sequence
- Met 1-Ser 594
- Characteristics
- A DNA sequence encoding the human STXBP1 isoform 1 (P61764-1) (Met 1-Ser 594) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product STXBP1 Protein
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Syntaxin Binding Protein 1 (STXBP1) (AA 74-168) protein (GST tag)
STXBP1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Syntaxin Binding Protein 1 (STXBP1) (AA 1-603) protein (GST tag)STXBP1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Syntaxin Binding Protein 1 (STXBP1) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)STXBP1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Syntaxin Binding Protein 1 (STXBP1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)STXBP1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 0.5 mM PMSF, 10 % glycerol, pH 8.0
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- STXBP1 (Syntaxin Binding Protein 1 (STXBP1))
- Alternative Name
- STXBP1/UNC18A (STXBP1 Products)
- Background
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Background: Syntaxin-binding protein 1, also known as N-Sec1, Protein unc-18 homolog 1, MUNC18-1 and STXBP1, is a peripheral membrane protein which belongs to the STXBP / unc-18 / SEC1 family. STXBP1 is an evolutionally conserved neuronal Sec1/Munc-18 (SM) protein that is essential in synaptic vesicle release in several species. It may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. STXBP1 is essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. It can interact with syntaxins 1, 2, and 3 but not syntaxin 4. STXBP1 may also play a role in determining the specificity of intracellular fusion reactions. Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4). Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
Synonym: MUNC18-1;NSEC1;P67;RBSEC1;UNC18
- Molecular Weight
- 95.4 kDa
- Pathways
- Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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