Complement Factor H Protein (CFH) (AA 875-1252) (His tag)
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- Target See all Complement Factor H (CFH) Proteins
- Complement Factor H (CFH)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 875-1252
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Complement Factor H protein is labelled with His tag.
- Purpose
- Mouse Factor H/CFH Protein
- Sequence
- Ser875-Val1252
- Characteristics
- Recombinant Mouse Factor H/CFH Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser875-Val1252.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product CFH Protein
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Complement Factor H (CFH) (AA 860-1231) protein (His tag)
CFH Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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Complement Factor H (CFH) (AA 1-449) protein (GST tag)CFH Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Complement Factor H (CFH) (AA 20-449) protein (GST tag)CFH Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Complement Factor H (CFH)
- Alternative Name
- Factor H (CFH Products)
- Background
- Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response.
- Molecular Weight
- 42.5 kDa. Due to glycosylation, the protein migrates to 60-65 kDa based on Tris-Bis PAGE result.
- NCBI Accession
- NP_034018
- Pathways
- Complement System, Cellular Response to Molecule of Bacterial Origin
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