Integrin alpha A1 beta 1 (ITGA1 & ITGB1) Heterodimer (AA 29-1141) protein (His tag)
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE
1 image
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- Target
- Integrin alpha A1 beta 1 (ITGA1 & ITGB1) Heterodimer
- Protein Type
- Recombinant
- Protein Characteristics
- AA 29-1141
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- His tag
- Purpose
- Human Integrin alpha 1 beta 1 (ITGA1 & ITGB1) Heterodimer Protein
- Sequence
- Phe29-Pro1141 (ITGA1) acidic tail & Gln21-Asp728 (ITGB1) basic tail
- Specificity
- Uni-Prot: P56199-1 (ITGA1), P05556-1 (ITGB1)
- Characteristics
- Recombinant Human Integrin alpha 1 beta 1 (ITGA1 & ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail.
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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Integrin alpha A1 beta 1 (ITGA1 & ITGB1) Heterodimer (AA 29-1141) protein (His tag)
Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in 50 mM Tris, 150 mM NaCl ( pH 7.5). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Integrin alpha A1 beta 1 (ITGA1 & ITGB1) Heterodimer
- Background
- Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen-binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.
- Molecular Weight
- 129.1 kDa(ITGA1)&83.2 kDa(ITGB1). Due to glycosylation, the protein migrates to 160-200 kDa based on Tris-Bis PAGE result.
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