Integrin alpha X beta 2 (ITGAX & ITGB2) Heterodimer (AA 20-1107) protein (His tag)
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Target
- Integrin alpha X beta 2 (ITGAX & ITGB2) Heterodimer
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-1107
- Origin
- Human
- Source
- HEK-293 Cells
- Purification tag / Conjugate
- His tag
- Purpose
- Human Integrin alpha X beta 2 (ITGAX & ITGB2) Heterodimer Protein
- Sequence
- Phe20-Pro1107 (ITGAX) acidic tail & Gln23-Asn700 (ITGB2) basic tail
- Specificity
- Uni-Prot: P20702-1 (ITGAX), P05107-1 (ITGB2)
- Characteristics
- Recombinant Human Integrin alpha X beta 2(ITGAX & ITGB2) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe20-Pro1107(ITGAX) acidic tail & Gln23-Asn700(ITGB2) basic tail.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Integrin alpha X beta 2 (ITGAX & ITGB2) Heterodimer
- Background
- The integrin alpha X beta 2 (CD11c/CD18, p150,95) binds ligands through the I domain of the alpha X subunit. Ligands include the complement factor fragment iC3b, a key component in the innate immune defense, which, together with the expression of alpha X beta 2 on dendritic cells and on other leukocytes, suggests a role in the immune response.
- Molecular Weight
- 125.50 kDa(ITGAX)&79.50 kDa(ITGB2). Due to glycosylation, the protein migrates to 130-135 kDa(ITGAX)&85-95 kDa(ITGB2) kDa based on Tris-Bis PAGE result.
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