Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer (AA 32-988) protein (His tag)
Origin: Mouse
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Target
- Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer
- Protein Type
- Recombinant
- Protein Characteristics
- AA 32-988
- Origin
- Mouse
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- His tag
- Purpose
- Mouse Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer Protein
- Sequence
- Leu32-Arg988 (ITGA2B) acidic tail & Glu26-Asp717 (ITGB3) basic tail
- Specificity
- Uni-Prot: Q9QUM0 (ITGA2B), O54890 (ITGB3)
- Characteristics
- Recombinant Mouse Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu32-Arg988(ITGA2B) acidic tail & Glu26-Asp717(ITGB3) basic tail.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer (AA 32-993) protein (His tag)
Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer
- Background
- Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction.
- Molecular Weight
- 109.80 kDa (ITGA2B)&80.80 kDa (ITGB3). Due to glycosylation, the protein migrates to 90-113 kDa based on Tris-Bis PAGE result.
- UniProt
- Q9QUM0
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