SLAMF7 Protein (AA 23-226) (mFc Tag)

Catalog No. ABIN7275631

Product Details

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Protein Type: Recombinant

Protein Characteristics: AA 23-226

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This SLAMF7 protein is labelled with mFc Tag.

Purpose: Human SLAMF7/CRACC/CD319 Protein

Sequence: Ser23-Met226

Characteristics: Recombinant Human SLAMF7/CRACC/CD319 Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Ser23-Met226

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human SLAMF7, mFc Tag at 0.2μg/ml (100μl/Well). Dose response curve for Anti-SLAMF7 Ab., hFc Tag with the EC50 of 13.52ng/ml determined by ELISA. See testing image for detail.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Alternative Name: SLAMF7 (SLAMF7 Products)

Background: CD2-like receptor activating cytotoxic cells (CRACC), also known as CS1, novel Ly9, SLAMF7, and CD319, is a 65-75 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family.Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.

Molecular Weight: 48.8 kDa. Due to glycosylation, the protein migrates to 68-72 kDa based on Tris-Bis PAGE result.