ENPP3 Protein (Fc Tag)
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- Target See all ENPP3 Proteins
- ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ENPP3 protein is labelled with Fc Tag.
- Purpose
- Human ENPP3 / CD203c Protein, Fc Tag (active enzyme, MALS verified)
- Sequence
- Leu 48 - Ile 875
- Characteristics
- Human ENPP3 Protein, Fc Tag is expressed from human 293 cells (HEK293). It contains AA Leu 48 - Ile 875 (Accession # O14638-1).
- Purity
- 90 %
- Endotoxin Level
- 1.0 EU per μg
- Grade
- MALS verified
- Top Product
- Discover our top product ENPP3 Protein
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Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) (AA 1-875) protein (His tag)
custom-made ENPP3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) (AA 1-874) protein (His tag)custom-made ENPP3 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) (AA 46-874) protein (His tag)ENPP3 Origin: Dog Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) (AA 558-875) protein (His tag)ENPP3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) (AA 48-157) protein (His-Avi Tag)ENPP3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) (AA 48-157) protein (His-Avi Tag,Biotin)ENPP3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) (AA 48-875) protein (His-Avi Tag,Biotin)ENPP3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) (AA 48-875) protein (His-Avi Tag)ENPP3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) (AA 602-699) protein (GST tag)ENPP3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) protein (Fc Tag)ENPP3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- Comment
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This protein carries a human IgG1 Fc tag at the N-terminus. (Fc) The protein has a calculated MW of 121.5 kDa. The protein migrates as 150-190 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target
- ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))
- Alternative Name
- ENPP3 (ENPP3 Products)
- Background
- The human NPP family contains seven members which can be classified into two groups according to their substrate preferences. The first class comprises the nucleotide-degrading proteins NPP1, 3 and 4. NPP3 (CD203c, ENPP3) is expressed in multiple organs, including on epithelial and mucosal surfaces, and notably on basophils and mast cells. Activation of basophils by antigen-bound IgE leads to release of inflammatory mediators and rapid upregulation of NPP3 to the cell surface. This protein is in fact a common marker for diagnosing allergen sensitivity with patient basophils by flow cytometry. Basophils and mast cells mediate the response to certain pathogens, as well as acute and chronic allergic reactions. Following activation, these cells release ATP, which further stimulates them in an autocrine manner. NPP3 upregulation serves to degrade ATP and suppress chronic allergic inflammation (but not the acute response).
- Molecular Weight
- 121.5 kDa
- Pathways
- Regulation of Muscle Cell Differentiation, Negative Regulation of Transporter Activity
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