SLC7A11 & SLC3A2 protein-VLP
Origin: Human
Host: HEK-293 Cells
VLP
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- Target
- SLC7A11 & SLC3A2
- Protein Type
- VLP
- Origin
- Human
- Source
- HEK-293 Cells
- Purpose
- Human SLC7A11&SLC3A2 Full Length Heterodimer Protein (VLP)
- Sequence
- Val 2 - Leu 501 (SLC7A11) & Glu 2- Ala 630 (SLC3A2)
- Characteristics
- Human SLC7A11&SLC3A2 Full Length Heterodimer Protein (VLP) is expressed from human 293 cells (HEK293). It contains AA Val 2 - Leu 501 (SLC7A11) & Glu 2- Ala 630 (SLC3A2) (Accession # Q9UPY5 (SLC7A11) & P08195 (SLC3A2).
- Endotoxin Level
- 1.0 EU per μg
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, Arginine, pH 7.4
- Storage
- -80 °C
- Storage Comment
- -70°C
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- Target
- SLC7A11 & SLC3A2
- Background
- Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability of cysteine. However, circulating cysteine exists in the blood as the oxidised di-peptide cystine, requiring specialised transport systems for its import into the cell. System xc- is a dedicated cystine transporter, importing cystine in exchange for intracellular glutamate. To counteract elevated levels of reactive oxygen species in cancerous cells system xc- is frequently upregulated, making it an attractive target for anticancer therapies.
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